Blood-brain barrier breakdown in COVID-19 ICU survivors: an MRI pilot study
Objectives: Coronavirus disease 2019 (COVID-19) results in severe inflammation at the acute stage. Chronic neuroinflammation and abnormal immunological response have been suggested to be the contributors to neuro-long-COVID, but direct evidence has been scarce. This study aims to determine the integrity of the blood-brain barrier (BBB) in COVID-19 intensive care unit (ICU) survivors using a novel MRI technique. Methods: COVID-19 ICU survivors (n=7) and age and sex-matched control participants (n=17) were recruited from June 2021 to March 2023. None of the control participants were hospitalized due to COVID-19 infection. The COVID-19 ICU survivors were studied at 98.6 ± 14.9 days after their discharge from ICU. A non-invasive MRI technique was used to assess the BBB permeability to water molecules, in terms of permeability surface area-product (PS) in the units of mL/100 g/min. Results: PS was significantly higher in COVID-19 ICU survivors (p=0.038) when compared to the controls, with values of 153.1 ± 20.9 mL/100 g/min and 132.5 ± 20.7 mL/100 g/min, respectively. In contrast, there were no significant differences in whole-brain cerebral blood flow (p=0.649) or brain volume (p=0.471) between the groups. Conclusions: There is preliminary evidence of a chronic BBB breakdown in COVID-19 survivors who had a severe acute infection, suggesting a plausible contributor to neurological long-COVID symptoms.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Blood-brain barrier breakdown in COVID-19 ICU survivors: an MRI pilot study ; volume:2 ; number:4 ; year:2023 ; pages:333-338 ; extent:6
NeuroImmune Pharmacology and Therapeutics ; 2, Heft 4 (2023), 333-338 (gesamt 6)
- Urheber
-
Shi, Wen
Jiang, Dengrong
Rando, Hannah
Khanduja, Shivalika
Lin, Zixuan
Hazel, Kaisha
Pottanat, George
Jones, Ebony
Xu, Cuimei
Lin, Doris
Yasar, Sevil
Cho, Sung-Min
Lu, Hanzhang
- DOI
-
10.1515/nipt-2023-0018
- URN
-
urn:nbn:de:101:1-2023120513215594672948
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:22 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Shi, Wen
- Jiang, Dengrong
- Rando, Hannah
- Khanduja, Shivalika
- Lin, Zixuan
- Hazel, Kaisha
- Pottanat, George
- Jones, Ebony
- Xu, Cuimei
- Lin, Doris
- Yasar, Sevil
- Cho, Sung-Min
- Lu, Hanzhang
Ähnliche Objekte (12)
Blood–brain barrier breakdown in dementia with Lewy bodies
Quantitative muscle MRI displays clinically relevant myostructural abnormalities in long-term ICU-survivors: a case–control study
Quantitative muscle MRI displays clinically relevant myostructural abnormalities in long-term ICU-survivors : a case–control study
Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study
Exposure to hyperbaric O2 levels leads to blood-brain barrier breakdown in rodents
Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors
Muscle weakness, functional capacities and recovery for COVID-19 ICU survivors
Association between RBC transfusion and 1-year mortality in ICU survivors
Endothelial edema precedes blood-brain barrier breakdown in early time points after experimental focal cerebral ischemia
Decoding microglia responses to psychosocial stress reveals blood-brain barrier breakdown that may drive stress susceptibility
Post ICU syndrome among survivors from respiratory critical illness. A prospective study
Management of COVID-19 ICU-survivors in primary care: - a narrative review
Blood–brain barrier breakdown in dementia with Lewy bodies
Quantitative muscle MRI displays clinically relevant myostructural abnormalities in long-term ICU-survivors: a case–control study
Quantitative muscle MRI displays clinically relevant myostructural abnormalities in long-term ICU-survivors : a case–control study
Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study
Exposure to hyperbaric O2 levels leads to blood-brain barrier breakdown in rodents
Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors
Muscle weakness, functional capacities and recovery for COVID-19 ICU survivors
Association between RBC transfusion and 1-year mortality in ICU survivors
Endothelial edema precedes blood-brain barrier breakdown in early time points after experimental focal cerebral ischemia
Decoding microglia responses to psychosocial stress reveals blood-brain barrier breakdown that may drive stress susceptibility
Post ICU syndrome among survivors from respiratory critical illness. A prospective study
Management of COVID-19 ICU-survivors in primary care: - a narrative review
Blood–brain barrier breakdown in dementia with Lewy bodies
Quantitative muscle MRI displays clinically relevant myostructural abnormalities in long-term ICU-survivors: a case–control study
Quantitative muscle MRI displays clinically relevant myostructural abnormalities in long-term ICU-survivors : a case–control study
Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study
Exposure to hyperbaric O2 levels leads to blood-brain barrier breakdown in rodents
Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors
Muscle weakness, functional capacities and recovery for COVID-19 ICU survivors
Association between RBC transfusion and 1-year mortality in ICU survivors
Endothelial edema precedes blood-brain barrier breakdown in early time points after experimental focal cerebral ischemia
Decoding microglia responses to psychosocial stress reveals blood-brain barrier breakdown that may drive stress susceptibility
Post ICU syndrome among survivors from respiratory critical illness. A prospective study