Potential of melatonin to reverse epigenetic aberrations in oral cancer : new findings

Abstract: It is now an accepted principle that epigenetic alterations cause cellular dyshomeostasis and functional changes, both of which are essential for the initiation and completion of the tumor cycle. Oral carcinogenesis is no exception in this regard, as most of the tumors in the different subsites of the oral cavity arise from the cross-reaction between (epi)genetic inheritance and the huge challenge of environmental stressors. Currently, the biochemical machinery is put at the service of the tumor program, halting the cell cycle, triggering uncontrolled proliferation, driving angiogenesis and resistance to apoptosis, until the archetypes of the tumor phenotype are reached. Melatonin has the ability to dynamically affect the epigenetic code. It has become accepted that melatonin can reverse (epi)genetic aberrations present in oral and other cancers, suggesting the possibility of enhancing the oncostatic capacity of standard multimodal treatments by incorporating this indolamine as an .... https://www.excli.de/excli/article/view/6624

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Potential of melatonin to reverse epigenetic aberrations in oral cancer ; volume:22 ; year:2023 ; EXCLI journal ; 22 (2023)

Contributors, Places and Time

• Creator: Gil-Martín, Emilio ; Ramos, Eva ; López-Muñoz, Francisco ; Egea, Javier ; Romero, Alejandro

Further information

• DOI: 10.17179/excli2023-6624
• URN: urn:nbn:de:101:1-2501170218551.886737280021
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:36 AM CEST