Potential biomarkers and molecular mechanisms in preeclampsia progression
Abstract: This study aimed to explore potential biomarkers and molecular mechanisms in preeclampsia (PE) progression. Gene expression profiles of GSE147776 and GSE96984 were downloaded, followed by the identification of common differentially expressed genes (co-DEGs) and common differentially expressed lncRNAs (co-DElncRNAs) in PE patients between the two datasets. Key genes were identified using gene set enrichment analysis (GSEA), followed by functional enrichment analyses. Subsequently, the miRNAs of key genes and miRNA-related lncRNAs were predicted, followed by the construction of the lncRNA–miRNA–gene ceRNA network. Furthermore, the key genes associated with different gestational stages were identified. As a result, 192 co-DEGs and 16 co-DElncRNAs were revealed from the two datasets. Based on two outstanding PE-associated pathways, including glaucoma and PE, identified by GSEA, ten key genes, including IGFBP1, CORIN, and C3, were revealed. Key genes, including IL1A and IL1B, were enriched in the developmental process involved in reproduction. Furthermore, ceRNAs, such as LINC00473-miR-4476-IL1A, LINC00473-miR-1291-IL1B, and NAV2-AS4-miR-6131-REN, were identified. Moreover, REN expression was significantly upregulated in the first- and second-trimester placentae compared to C-section-term placentae. In conclusion, these key genes may serve as novel biomarkers for PE. The detection of REN expression may help in the early prediction of PE and the initiation of prophylactic medical treatment.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Potential biomarkers and molecular mechanisms in preeclampsia progression ; volume:17 ; number:1 ; year:2022 ; pages:529-543 ; extent:15
Open life sciences ; 17, Heft 1 (2022), 529-543 (gesamt 15)
- Creator
-
Li, Guohua
Huang, Shijia
Liu, Xiaosong
Du, Qiaoling
- DOI
-
10.1515/biol-2022-0053
- URN
-
urn:nbn:de:101:1-2022071516465214104139
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:32 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Li, Guohua
- Huang, Shijia
- Liu, Xiaosong
- Du, Qiaoling
Other Objects (12)
Molecular mechanisms of HPV mediated neoplastic progression
Molecular mechanisms and biomarkers of familial FTD/ALS
Immature Platelet Fraction and Thrombin Generation: Preeclampsia Biomarkers
Maternal plasma proteome profiling of biomarkers and pathogenic mechanisms of early-onset and late-onset preeclampsia
Molecular mechanisms of microRNA-216a during tumor progression
Molecular mechanisms in progression of HPV-associated cervical carcinogenesis
Molecular mechanisms of neuroendocrine differentiation in prostate cancer progression
Potential molecular mechanisms and clinical implications of piRNAs in preeclampsia: a review
Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies
Molecular mechanisms of EBV-driven cell cycle progression and oncogenesis
Integrating multiple ‘omics’ analyses identifies serological protein biomarkers for preeclampsia
The underlying molecular mechanisms and biomarkers between periodontitis and COVID-19
Molecular mechanisms of HPV mediated neoplastic progression
Molecular mechanisms and biomarkers of familial FTD/ALS
Immature Platelet Fraction and Thrombin Generation: Preeclampsia Biomarkers
Maternal plasma proteome profiling of biomarkers and pathogenic mechanisms of early-onset and late-onset preeclampsia
Molecular mechanisms of microRNA-216a during tumor progression
Molecular mechanisms in progression of HPV-associated cervical carcinogenesis
Molecular mechanisms of neuroendocrine differentiation in prostate cancer progression
Potential molecular mechanisms and clinical implications of piRNAs in preeclampsia: a review
Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies
Molecular mechanisms of EBV-driven cell cycle progression and oncogenesis
Integrating multiple ‘omics’ analyses identifies serological protein biomarkers for preeclampsia
The underlying molecular mechanisms and biomarkers between periodontitis and COVID-19
Molecular mechanisms of HPV mediated neoplastic progression
Molecular mechanisms and biomarkers of familial FTD/ALS
Immature Platelet Fraction and Thrombin Generation: Preeclampsia Biomarkers
Maternal plasma proteome profiling of biomarkers and pathogenic mechanisms of early-onset and late-onset preeclampsia
Molecular mechanisms of microRNA-216a during tumor progression
Molecular mechanisms in progression of HPV-associated cervical carcinogenesis
Molecular mechanisms of neuroendocrine differentiation in prostate cancer progression
Potential molecular mechanisms and clinical implications of piRNAs in preeclampsia: a review
Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies
Molecular mechanisms of EBV-driven cell cycle progression and oncogenesis
Integrating multiple ‘omics’ analyses identifies serological protein biomarkers for preeclampsia