Utility of 2-(4,5-dihydro-4-oxothiazol-2-yl) acetonitrile in the synthesis of fused heterocyclic derivatives with anti-tumor ac tivities
Abstract: 2-(4,5-Dihydro-4-oxothiazol-2-yl) acetonitrile (1) was reacted with acetophenone (2) to give 2-(4,5-dihydro-4-oxothiazol-2-yl)-3-phenylbut-2-enenitrile (3). The reactivity of product 3towards aromatic aldehydes 4a–d, cyanomethylene reagents 6a,b, aryl diazonium salts 10a–d, phenylisothiocyanate and elemental sulfur was studied. Some of the newly synthesized compounds were used to synthesize fused derivatives. The anti-tumor evaluation of selected compounds against three cancer cells namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that some of them have a high inhibitory effect and compound 19 was found to be more active than the standard on NCI-H460 and SF-268.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Utility of 2-(4,5-dihydro-4-oxothiazol-2-yl) acetonitrile in the synthesis of fused heterocyclic derivatives with anti-tumor ac tivities ; volume:17 ; number:3-4 ; year:2011 ; pages:155-160
Heterocyclic communications ; 17, Heft 3-4 (2011), 155-160
- Creator
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Wardakhan, Wagnat W.
Ibrahim, Diaa A.
Zaki, Mayssoune Y.
- DOI
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10.1515/hc.2011.033
- URN
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urn:nbn:de:101:1-2501140315010.117755072126
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:21 AM CEST
Data provider
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Associated
- Wardakhan, Wagnat W.
- Ibrahim, Diaa A.
- Zaki, Mayssoune Y.
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