Neuropathology and epilepsy surgery – 2024 update

Abstract: Neuropathology-based studies in neurosurgically resected brain tissue obtained from carefully examined patients with focal epilepsies remain a treasure box for excellent insights into human neuroscience, including avenues to better understand the neurobiology of human brain organization and neuronal hyperexcitability at the cellular level including glio-neuronal interaction. It also allows to translate results from animal models in order to develop personalized treatment strategies in the near future. A nice example of this is the discovery of a new disease entity in 2017, termed mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy or MOGHE, in the frontal lobe of young children with intractable seizures. In 2021, a brain somatic missense mutation of the galactose transporter SLC35A2 leading to altered glycosylation of lipoproteins in the Golgi apparatus was detected in 50 % of MOGHE samples. In 2023, the first clinical trial evaluated galactose s.... https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/5347

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Neuropathology and epilepsy surgery – 2024 update ; volume:5 ; year:2024 ; Free Neuropathology ; 5 (2024)

Contributors, Places and Time

• Creator: Blümcke, Ingmar

Further information

• DOI: 10.17879/freeneuropathology-2024-5347
• URN: urn:nbn:de:hbz:6:3-freeneuropathology-2024-56067
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:52 AM CEST