Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy
Abstract: Helicobacter pylori (H. pylori) is a primary pathogen associated with gastrointestinal diseases, including gastric cancer. The increase in resistance to antibiotics, along with the adverse effects caused by complicated medication protocols, has made the eradication of H. pylori a more formidable challenge, necessitating alternative therapeutics. Herein, a targeted nanoplatform is reported based on sonodynamic therapy, the chitosan‐conjugated fucose loaded with indocyanine green (ICG@FCS). It penetrates the gastric mucosa and homes in on H. pylori through dual targeting mechanisms: molecular via fucose and physical via ultrasound. Upon ultrasound activation, it generates singlet oxygen, effectively attacking planktonic bacteria, disrupting biofilms, and facilitating the clearance of intracellular bacteria by promoting autophagy, including multidrug‐resistant strains. The ICG@FCS nanoplatform minimally affects the gut microbiota and aids in gastric mucosa repair. a holistic integrative H. pylori therapy strategy is proposed that targets eradication while preserving gastrointestinal health. This strategy emphasizes the importance of maintaining patient health while eradicating the pathogen. This advancement is set to refine the comprehensive antibacterial approach, offering a promising horizon in the ongoing battle against antibiotic resistance and more effective gastric cancer prevention strategies.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy ; day:13 ; month:11 ; year:2024 ; extent:17
Advanced science ; (13.11.2024) (gesamt 17)
- Creator
-
Yin, Xiaojing
Lai, Yongkang
Zhang, Xinyuan
Zhang, Tingling
Tian, Jing
Du, Yiqi
Li, Zhaoshen
Gao, Jie
- DOI
-
10.1002/advs.202408583
- URN
-
urn:nbn:de:101:1-2411131355047.789850580173
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:28 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Yin, Xiaojing
- Lai, Yongkang
- Zhang, Xinyuan
- Zhang, Tingling
- Tian, Jing
- Du, Yiqi
- Li, Zhaoshen
- Gao, Jie
Other Objects (12)
Konzeption und Realisierung von Vorlagen im MAVA-System
Rational action without knowledge (and vice versa)
China’s Bank Reform and the Roles of Sovereign Wealth Fund
Sources of Mathematics Self-Efficacy in Chinese Students: a Mixed-Method Study with Q-Sorting Procedure
Konzeption und Realisierung von Workflow-Wrappern mit SQL/MED
CEPC Technical Design Report: Accelerator
Video face target detection and tracking algorithm based on nonlinear sequence Monte Carlo filtering technique
PPIs therapy has a negative impact on the clinical outcomes of advanced SCLC patients treated with PD-L1 inhibitors
Near-infrared photodynamic and photothermal co-therapy based on organic small molecular dyes
Sensitive and reliable miRNA analysis based on cyclic reverse transcription and CRISPR-Cas12a-assisted signal cycle
Aptamer-based protein molecule detection via cyclic reverse transcription coupling with self-priming hairpin-triggered CRISPR-Cas12a system
Global exponential synchronization of networked dynamical systems under event-triggered control schemes
Konzeption und Realisierung von Vorlagen im MAVA-System
Rational action without knowledge (and vice versa)
China’s Bank Reform and the Roles of Sovereign Wealth Fund
Sources of Mathematics Self-Efficacy in Chinese Students: a Mixed-Method Study with Q-Sorting Procedure
Konzeption und Realisierung von Workflow-Wrappern mit SQL/MED
CEPC Technical Design Report: Accelerator
Video face target detection and tracking algorithm based on nonlinear sequence Monte Carlo filtering technique
PPIs therapy has a negative impact on the clinical outcomes of advanced SCLC patients treated with PD-L1 inhibitors
Near-infrared photodynamic and photothermal co-therapy based on organic small molecular dyes
Sensitive and reliable miRNA analysis based on cyclic reverse transcription and CRISPR-Cas12a-assisted signal cycle
Aptamer-based protein molecule detection via cyclic reverse transcription coupling with self-priming hairpin-triggered CRISPR-Cas12a system
Global exponential synchronization of networked dynamical systems under event-triggered control schemes
Konzeption und Realisierung von Vorlagen im MAVA-System
Rational action without knowledge (and vice versa)
China’s Bank Reform and the Roles of Sovereign Wealth Fund
Sources of Mathematics Self-Efficacy in Chinese Students: a Mixed-Method Study with Q-Sorting Procedure
Konzeption und Realisierung von Workflow-Wrappern mit SQL/MED
CEPC Technical Design Report: Accelerator
Video face target detection and tracking algorithm based on nonlinear sequence Monte Carlo filtering technique
PPIs therapy has a negative impact on the clinical outcomes of advanced SCLC patients treated with PD-L1 inhibitors
Near-infrared photodynamic and photothermal co-therapy based on organic small molecular dyes
Sensitive and reliable miRNA analysis based on cyclic reverse transcription and CRISPR-Cas12a-assisted signal cycle
Aptamer-based protein molecule detection via cyclic reverse transcription coupling with self-priming hairpin-triggered CRISPR-Cas12a system