Macroautophagy proteins control MHC class I levels on dendritic cells and shape anti-viral CD8 + T cell responses
Abstract: Macroautophagy assists in antigen processing for MHC class II presentation. In contrast to this supportive role for CD4 + T cell stimulation, Loi et al. demonstrate that macroautophagy proteins diminish antigen presentation on MHC class I molecules during anti-viral CD8 + T cell responses by supporting MHC class I internalization in dendritic cells
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Cell reports. - 15, 5 (2016) , 1076-1087, ISSN: 2211-1247
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2025
- Creator
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Loi, Monica
Müller, Anne
Steinbach, Karin
Niven, Jennifer
Barreira da Silva, Rosa
Paul, Petra
Ligeon, Laure-Anne
Caruso, Assunta
Albrecht, Randy A.
Becker, Andrea Claudia
Annaheim, Nicolas
Nowag, Heike
Dengjel, Jörn
García-Sastre, Adolfo
Merkler, Doron
Münz, Christian
Gannagé, Monique
- Contributor
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FRIAS Natur- und Lebenswissenschaften, Medizin und Ingenieurwissenschaften
- DOI
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10.1016/j.celrep.2016.04.002
- URN
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urn:nbn:de:bsz:25-freidok-1321361
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:24 AM CEST
Data provider
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Associated
- Loi, Monica
- Müller, Anne
- Steinbach, Karin
- Niven, Jennifer
- Barreira da Silva, Rosa
- Paul, Petra
- Ligeon, Laure-Anne
- Caruso, Assunta
- Albrecht, Randy A.
- Becker, Andrea Claudia
- Annaheim, Nicolas
- Nowag, Heike
- Dengjel, Jörn
- García-Sastre, Adolfo
- Merkler, Doron
- Münz, Christian
- Gannagé, Monique
- FRIAS Natur- und Lebenswissenschaften, Medizin und Ingenieurwissenschaften
- Universität
Time of origin
- 2025
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MHC-based detection of antigen-specific CD8+ T cell responses
Analysis of CD40L-expressing CD8+ T cells in antiviral immunity
The MHC I peptide-loading complex in human dendritic cells
Regulatory T cells limit antiviral CD8 T cell responses through IL-2 competition
Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells
Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells
Aurora A controls CD8+ T cell cytotoxic activity and antiviral response
Impaired CD8 T cell antiviral immunity following acute spinal cord injury
Modulation of the MHC I peptide loading complex in dendritic cells
Effects of commonly used antiviral vaccines on human plasmacytoid dendritic cells
Generation of functional CD8+ T Cells by human dendritic cells expressing glypican-3 epitopes
Immune synapse formation promotes lipid peroxidation and MHC-I upregulation in licensed dendritic cells for efficient priming of CD8+ T cells
MHC-based detection of antigen-specific CD8+ T cell responses
Analysis of CD40L-expressing CD8+ T cells in antiviral immunity
The MHC I peptide-loading complex in human dendritic cells
Regulatory T cells limit antiviral CD8 T cell responses through IL-2 competition
Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells
Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells
Aurora A controls CD8+ T cell cytotoxic activity and antiviral response
Impaired CD8 T cell antiviral immunity following acute spinal cord injury
Modulation of the MHC I peptide loading complex in dendritic cells
Effects of commonly used antiviral vaccines on human plasmacytoid dendritic cells