Inhibition of Integrin α v β 6 Activation of TGF‐ β Attenuates Tendinopathy
Abstract: Tendinopathy is a common tendon disorder that causes pain and impairs function. It is the most common reason for consultation with musculoskeletal specialists. The available therapies for tendinopathy are limited in number and efficacy and have unclear cellular and molecular mechanisms. Here it is shown that transforming growth factor‐beta (TGF‐β) activated by integrin αvβ6 promotes tendinopathy in mice. Excessive active TGF‐β is found during tendinopathy progression, which led to tenocytes’ phenotype transition to chondrocytes. Transgenic expression of active TGF‐β in tendons induced spontaneous tendinopathy, whereas systemic injection of a TGF‐β neutralizing antibody attenuated tendinopathy. Inducible knockout of the TGF‐β type 2 receptor gene (Tgfbr2) in tenocytes inhibited tendinopathy progression in mice. Moreover, it is found that integrin αvβ6 induces TGF‐β activation in response to mechanical load in tendons. Conditional knockout of the integrin αv gene in tendons prevented tendinopathy in mice. The study suggests that integrin αvβ6 activation of TGF‐β is the mechanism of tendinopathy, and that integrin αvβ6 may be a therapeutic target in tendinopathy.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Inhibition of Integrin α v β 6 Activation of TGF‐ β Attenuates Tendinopathy ; day:15 ; month:02 ; year:2022 ; extent:14
Advanced science ; (15.02.2022) (gesamt 14)
- Creator
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Wang, Xiao
Liu, Shen
Yu, Tao
An, Senbo
Deng, Ruoxian
Tan, Xiaohua
Crane, Janet
Zhang, Weixin
Pan, Dayu
Wan, Mei
Carr, Andrew
Cao, Xu
- DOI
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10.1002/advs.202104469
- URN
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urn:nbn:de:101:1-2022021514040672829698
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:34 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Wang, Xiao
- Liu, Shen
- Yu, Tao
- An, Senbo
- Deng, Ruoxian
- Tan, Xiaohua
- Crane, Janet
- Zhang, Weixin
- Pan, Dayu
- Wan, Mei
- Carr, Andrew
- Cao, Xu
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