Synthesis of Mucin O‐Glycans Associated with Attenuation of Pathogen Virulence
Abstract: With the concerning rise in antibiotic‐resistant infections, novel treatment options against pathogens are urgently sought. Several recent studies have identified mucin O‐glycan mixtures as potent down‐regulators of virulence‐related gene expression in diverse pathogens. As individual mucin glycans cannot be isolated in sufficient purity and quantity for biological evaluation of discrete structures, we have developed an optimized synthetic approach to generate a small library of mucin glycans which were identified as most likely to display activity. The glycans have been prepared in sufficient quantity to assess biological function, studies of which are currently ongoing.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Synthesis of Mucin O‐Glycans Associated with Attenuation of Pathogen Virulence ; day:26 ; month:07 ; year:2022 ; extent:1
ChemistryOpen ; (26.07.2022) (gesamt 1)
- Creator
-
Minzer, Giulietta
Hevey, Rachel
- DOI
-
10.1002/open.202200134
- URN
-
urn:nbn:de:101:1-2022072615111782954340
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:20 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Minzer, Giulietta
- Hevey, Rachel
Other Objects (12)
Ion mobility-tandem mass spectrometry of mucin-type O-glycans
Mucin-derived O-glycans supplemented to diet mitigate diverse microbiota perturbations
Mucin induces CRISPR-Cas defense in an opportunistic pathogen
Simulated digestions of free oligosaccharides and mucin-type O-glycans reveal a potential role for Clostridium perfringens
Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
The role of immunity in mosquito-induced attenuation of malaria virulence
Evolution of pathogen virulence : Studying the complex interplay of pathogen interactions, virulence and transmission helps us understand how they evolve and spread
Host‐derived O ‐glycans inhibit toxigenic conversion by a virulence‐encoding phage in Vibrio cholerae
Within-host evolution decreases virulence in an opportunistic bacterial pathogen
Diplodia tip blight pathogen’s virulence empowered through host switch
Investigation of Candida parapsilosis virulence regulatory factors during host-pathogen interaction
Ago1 Affects the Virulence of the Fungal Plant Pathogen Zymoseptoria tritici
Ion mobility-tandem mass spectrometry of mucin-type O-glycans
Mucin-derived O-glycans supplemented to diet mitigate diverse microbiota perturbations
Mucin induces CRISPR-Cas defense in an opportunistic pathogen
Simulated digestions of free oligosaccharides and mucin-type O-glycans reveal a potential role for Clostridium perfringens
Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
The role of immunity in mosquito-induced attenuation of malaria virulence
Evolution of pathogen virulence : Studying the complex interplay of pathogen interactions, virulence and transmission helps us understand how they evolve and spread
Host‐derived O ‐glycans inhibit toxigenic conversion by a virulence‐encoding phage in Vibrio cholerae
Within-host evolution decreases virulence in an opportunistic bacterial pathogen
Diplodia tip blight pathogen’s virulence empowered through host switch
Investigation of Candida parapsilosis virulence regulatory factors during host-pathogen interaction
Ago1 Affects the Virulence of the Fungal Plant Pathogen Zymoseptoria tritici
Ion mobility-tandem mass spectrometry of mucin-type O-glycans
Mucin-derived O-glycans supplemented to diet mitigate diverse microbiota perturbations
Mucin induces CRISPR-Cas defense in an opportunistic pathogen
Simulated digestions of free oligosaccharides and mucin-type O-glycans reveal a potential role for Clostridium perfringens
Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
The role of immunity in mosquito-induced attenuation of malaria virulence
Evolution of pathogen virulence : Studying the complex interplay of pathogen interactions, virulence and transmission helps us understand how they evolve and spread
Host‐derived O ‐glycans inhibit toxigenic conversion by a virulence‐encoding phage in Vibrio cholerae
Within-host evolution decreases virulence in an opportunistic bacterial pathogen
Diplodia tip blight pathogen’s virulence empowered through host switch
Investigation of Candida parapsilosis virulence regulatory factors during host-pathogen interaction