Vibrational Circular Dichroism Spectroscopy of Chiral Molecular Crystals: Insights from Theory

Abstract: Chirality is a curious phenomenon that appears in various forms. While the concept of molecular (RS‐) chirality is ubiquitous in chemistry, there are also more intricate forms of structural chirality. One of them is the enantiomorphism of crystals, especially molecular crystals, that describes the lack of mirror symmetry in the unit cell. Its relation to molecular chirality is not obvious, but still an open question, which can be addressed with chiroptical tools. Vibrational circular dichroism (VCD) denotes chiral infrared (IR) spectroscopy that is susceptible to both, the molecular as well as the intermolecular space by means of vibrational transitions. When carried out in the solid state, VCD delivers a very rich set of non‐local contributions that are determined by crystal packing and collective motion. Since its discovery in the 1970s, VCD has become the method of choice for the determination of absolute configurations, but its applicability reaches beyond towards the study of different crystal forms and polymorphism. This brief review summarises the theoretical concepts of crystal chirality and how computations of solid‐state VCD can shed light into the intimate connection of chiral structure and vibrational optical activity.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Vibrational Circular Dichroism Spectroscopy of Chiral Molecular Crystals: Insights from Theory ; day:02 ; month:07 ; year:2023 ; extent:12 ; Angewandte Chemie ; (02.07.2023) (gesamt 12)

Contributors, Places and Time

• Creator: Jähnigen, Sascha

Further information

• DOI: 10.1002/ange.202303595
• URN: urn:nbn:de:101:1-2023070315132010149819
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 11:03 AM CEST