Noninvasive Stimulation of Peripheral Nerves using Temporally‐Interfering Electrical Fields
Abstract: Electrical stimulation of peripheral nerves is a cornerstone of bioelectronic medicine. Effective ways to accomplish peripheral nerve stimulation (PNS) noninvasively without surgically implanted devices are enabling for fundamental research and clinical translation. Here, it is demonstrated how relatively high‐frequency sine‐wave carriers (3 kHz) emitted by two pairs of cutaneous electrodes can temporally interfere at deep peripheral nerve targets. The effective stimulation frequency is equal to the offset frequency (0.5 – 4 Hz) between the two carriers. This principle of temporal interference nerve stimulation (TINS) in vivo using the murine sciatic nerve model is validated. Effective actuation is delivered at significantly lower current amplitudes than standard transcutaneous electrical stimulation. Further, how flexible and conformable on‐skin multielectrode arrays can facilitate precise alignment of TINS onto a nerve is demonstrated. This method is simple, relying on the repurposing of existing clinically‐approved hardware. TINS opens the possibility of precise noninvasive stimulation with depth and efficiency previously impossible with transcutaneous techniques.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Noninvasive Stimulation of Peripheral Nerves using Temporally‐Interfering Electrical Fields ; day:07 ; month:07 ; year:2022 ; extent:10
Advanced healthcare materials ; (07.07.2022) (gesamt 10)
- Urheber
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Botzanowski, Boris
Donahue, Mary J.
Ejneby, Malin Silverå
Gallina, Alessandro L.
Ngom, Ibrahima
Missey, Florian
Acerbo, Emma
Byun, Donghak
Carron, Romain
Cassarà, Antonino M.
Neufeld, Esra
Jirsa, Viktor
Olofsson, Peder S.
Głowacki, Eric
Williamson, Adam
- DOI
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10.1002/adhm.202200075
- URN
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urn:nbn:de:101:1-2022070815082007847577
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:20 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Botzanowski, Boris
- Donahue, Mary J.
- Ejneby, Malin Silverå
- Gallina, Alessandro L.
- Ngom, Ibrahima
- Missey, Florian
- Acerbo, Emma
- Byun, Donghak
- Carron, Romain
- Cassarà, Antonino M.
- Neufeld, Esra
- Jirsa, Viktor
- Olofsson, Peder S.
- Głowacki, Eric
- Williamson, Adam
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