Podocytes: recent biomolecular developments
Abstract: Podocytes are postmitotic renal glomerular cells with multiple ramifications that extend from the cell body. Processes departing from a podocyte interdigitate with corresponding projections from neighboring cells and form an intricate web that enwraps the glomerular capillary completely. Podocyte processes are interconnected by the slit diaphragm, an adhesion junction mostly formed by Ig-like molecules, cadherins/protocadherins, ephrin/eph, and neurexin molecules organized in an assembly that resembles synaptic junctions. Podocyte failure is primarily or secondarily implicated in all forms of proteinuric glomerular diseases, as confirmed by the morphological changes of their elaborate cell architecture detectable by electron microscopy. Importantly, mutations of podocyte proteins are responsible for the most severe forms of congenital nephrotic syndrome. In the last 15 years, progressive technological advances have aided the study of podocyte biology and pathology, confirming the relevance of podocyte molecules and signaling pathways for the function of the glomerular filter. This review will examine the most important and newest discoveries in the field, which is rapidly evolving, hopefully leading to a detailed knowledge of this fascinating cell and to the development of specific therapeutic options for proteinuric diseases.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Podocytes: recent biomolecular developments ; volume:5 ; number:4 ; year:2014 ; pages:319-330 ; extent:12
Biomolecular concepts ; 5, Heft 4 (2014), 319-330 (gesamt 12)
- Urheber
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Armelloni, Silvia
Corbelli, Alessandro
Giardino, Laura
Li, Min
Ikehata, Masami
Mattinzoli, Deborah
Messa, Piergiorgio
Pignatari, Chiara
Watanabe, Shojiro
Rastaldi, Maria Pia
- DOI
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10.1515/bmc-2014-0020
- URN
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urn:nbn:de:101:1-2409241619297.548687152708
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:32 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Armelloni, Silvia
- Corbelli, Alessandro
- Giardino, Laura
- Li, Min
- Ikehata, Masami
- Mattinzoli, Deborah
- Messa, Piergiorgio
- Pignatari, Chiara
- Watanabe, Shojiro
- Rastaldi, Maria Pia
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