Oxygen-supplied electrotherapy for enhanced photodynamic synergistic therapy overcomes hypoxia tumor microenvironment
Abstract: Photodynamic therapy (PDT) has lately been identified as a promising anticancer method and gained tremendous interest due to its controllability, non-invasive nature, and negligible side effects. Nevertheless, the development of PDT is hampered by two factors. One is the insufficient tissue penetration of phototherapy laser, resulting in restricted treatment sites. Another one is the substantial dependence of reactive oxygen species (ROS) formation on oxygen concentration. Therefore, a strategy to promote ROS generation by overcoming the hypoxia microenvironment is critical to cancer therapy. Electrolysis of water is known to be a rapid and relatively secure method for producing oxygen. Thus, in this study, electrotherapy was introduced to alleviate the tumor hypoxia by producing oxygen in situ, hence boosting the PDT efficacy, namely E-PDT. Black phosphorus (BP) based nanomaterials were selected as clearable photosensitizers with outstanding PDT performance. Experiments conducted both in vitro and in vivo indicated that E-PDT performed superior therapeutic effects with the in situ generation of oxygen by electrotherapy compared with other groups. This work suggests a promising strategy for phototherapeutic anticancer efficiency enhancement.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Oxygen-supplied electrotherapy for enhanced photodynamic synergistic therapy overcomes hypoxia tumor microenvironment ; volume:11 ; number:22 ; year:2022 ; pages:5077-5088 ; extent:12
Nanophotonics ; 11, Heft 22 (2022), 5077-5088 (gesamt 12)
- Urheber
-
Li, Chaozhou
Tan, Hui
Lu, Ruitao
Qin, Sainan
Meng, Xiangying
Zhang, Han
Xie, Zhongjian
- DOI
-
10.1515/nanoph-2022-0417
- URN
-
urn:nbn:de:101:1-2022121313070310446732
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:30 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Li, Chaozhou
- Tan, Hui
- Lu, Ruitao
- Qin, Sainan
- Meng, Xiangying
- Zhang, Han
- Xie, Zhongjian
Ähnliche Objekte (12)
Novel two-dimensional materials based bio-nanophotonics
An ensemble method to predict target genes and pathways in uveal melanoma
Impact of air pollution prevention and control on urban green economy efficiency: evidence from China
Three birds with one stone: oxygen self-supply engineering palladium nanocluster/titanium carbide hybrid for single-NIR laser-triggered synergistic photodynamic-photothermal therapy
Towards a typology of university technology transfer organizations in China: Evidences from Tsinghua University
Comparative efficacy of different treatments for menstrual migraine: a systematic review and network meta-analysis
Pursue the truth, devote to education: Chen Hua-Kui, a respectable educator and pioneer of China’s soil microbiology
Distributed stochastic gradient descent for link prediction in signed social networks
Towards a typology of university technology transfer organizations in China: evidences from Tsinghua University
Discrete-time inverse linear quadratic optimal control over finite time-horizon under noisy output measurements
Nano‐Engineered Carbon Fibre‐Based Piezoelectric Smart Composites for Energy Harvesting and Self‐Powered Sensing
People are more error-prone after committing an error
Novel two-dimensional materials based bio-nanophotonics
An ensemble method to predict target genes and pathways in uveal melanoma
Impact of air pollution prevention and control on urban green economy efficiency: evidence from China
Three birds with one stone: oxygen self-supply engineering palladium nanocluster/titanium carbide hybrid for single-NIR laser-triggered synergistic photodynamic-photothermal therapy
Towards a typology of university technology transfer organizations in China: Evidences from Tsinghua University
Comparative efficacy of different treatments for menstrual migraine: a systematic review and network meta-analysis
Pursue the truth, devote to education: Chen Hua-Kui, a respectable educator and pioneer of China’s soil microbiology
Distributed stochastic gradient descent for link prediction in signed social networks
Towards a typology of university technology transfer organizations in China: evidences from Tsinghua University
Discrete-time inverse linear quadratic optimal control over finite time-horizon under noisy output measurements
Nano‐Engineered Carbon Fibre‐Based Piezoelectric Smart Composites for Energy Harvesting and Self‐Powered Sensing
People are more error-prone after committing an error
Novel two-dimensional materials based bio-nanophotonics
An ensemble method to predict target genes and pathways in uveal melanoma
Impact of air pollution prevention and control on urban green economy efficiency: evidence from China
Three birds with one stone: oxygen self-supply engineering palladium nanocluster/titanium carbide hybrid for single-NIR laser-triggered synergistic photodynamic-photothermal therapy
Towards a typology of university technology transfer organizations in China: Evidences from Tsinghua University
Comparative efficacy of different treatments for menstrual migraine: a systematic review and network meta-analysis
Pursue the truth, devote to education: Chen Hua-Kui, a respectable educator and pioneer of China’s soil microbiology
Distributed stochastic gradient descent for link prediction in signed social networks
Towards a typology of university technology transfer organizations in China: evidences from Tsinghua University
Discrete-time inverse linear quadratic optimal control over finite time-horizon under noisy output measurements
Nano‐Engineered Carbon Fibre‐Based Piezoelectric Smart Composites for Energy Harvesting and Self‐Powered Sensing