Electric Conductivity on Aligned Nanofibers Facilitates the Transdifferentiation of Mesenchymal Stem Cells into Schwann Cells and Regeneration of Injured Peripheral Nerve

to related objects

Abstract: Schwann cells (SCs) are the most promising seed cells for peripheral nerve tissue engineering, but clinical applications are limited by the lack of cell sources. Existing data demonstrate that bone marrow mesenchymal stem cells (BMSCs) can be induced to differentiate into Schwann‐like cells and aligned nanofibers can enhance the differentiation. Considering that SCs are living along with the electrical conductive axons, it is hypothesized that conductivity properties may play roles in SCs differentiation and then facilitate nerve regeneration. To verify this hypothesis, amine functionalized multi‐walled carbon nanotubes (MWCNTs) are incorporated with polycaprolactone and gelatin to fabricate aligned or random conductive nanofibers by electrospinning. Current data demonstrate that MWCNTs can dramatically increase the electrical conductive properties but do not alter the biocompatibility of the nanofibers. It is found that endowing conductive properties into the aligned nanofibers can significantly enhance their capability to promote the SCs differentiation. Furthermore, the aligned and conductive nanofibers with induced BMSCs can dramatically promote peripheral axonal regeneration. Collectively, the present study demonstrates that the conductive properties in the aligned nanofiber plays significant roles in SCs differentiation and the aligned and conductive nanofibers can be used as a promising scaffold for SCs differentiation and peripheral nerve tissue engineering.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Electric Conductivity on Aligned Nanofibers Facilitates the Transdifferentiation of Mesenchymal Stem Cells into Schwann Cells and Regeneration of Injured Peripheral Nerve ; volume:9 ; number:11 ; year:2020 ; extent:12
Advanced healthcare materials ; 9, Heft 11 (2020) (gesamt 12)

Creator: Hu, Xiaofang
Wang, Xianghai
Xu, Yizhou
Li, Lixia
Liu, Jingmin
He, Yutong
Zou, Ying
Yu, Lei
Qiu, Xiaozhong
Guo, Jiasong

DOI: 10.1002/adhm.201901570

URN: urn:nbn:de:101:1-2022062807301073711899

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:30 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Show original at data provider

Associated

Hu, Xiaofang
Wang, Xianghai
Xu, Yizhou
Li, Lixia
Liu, Jingmin
He, Yutong
Zou, Ying
Yu, Lei
Qiu, Xiaozhong
Guo, Jiasong

Other Objects (12)

Ground-level ozone (O3) pollution and its impacts on vegetation: an attribute to Prof. Evgenios Agathokleous

The effect of methanol fixation on single-cell RNA sequencing data

Correction to: The effect of methanol fixation on single-cell RNA sequencing data

AI-empowered game architecture and application for resource provision and scheduling in multi-clouds

The deconstruction of emotional identity of recreation for ethnic cultural heritage in the geo-cultural perspective: a fuzzy set qualitative comparative analysis on Wuqiang new year paintings

Role of periostin in ECRS

BMAL1 plays a critical role in the protection against cardiac hypertrophy through autophagy in vitro

Hyperbolic Tangent-Type Variant-Parameter and Robust ZNN Solutions for Resolving Time-Variant Sylvester Equation in Preassigned-Time

Experimental Sensing and Density Functional Theory Study of H 2 S and SOF 2 Adsorption on Au‐Modified Graphene

Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy

LINC01287 facilitates proliferation, migration, invasion and EMT of colon cancer cells via miR-4500/MAP3K13 pathway

SLC5A2 mutations, including two novel mutations, responsible for renal glucosuria in Chinese families

Ground-level ozone (O3) pollution and its impacts on vegetation: an attribute to Prof. Evgenios Agathokleous

The effect of methanol fixation on single-cell RNA sequencing data

Correction to: The effect of methanol fixation on single-cell RNA sequencing data

AI-empowered game architecture and application for resource provision and scheduling in multi-clouds

The deconstruction of emotional identity of recreation for ethnic cultural heritage in the geo-cultural perspective: a fuzzy set qualitative comparative analysis on Wuqiang new year paintings

Role of periostin in ECRS

BMAL1 plays a critical role in the protection against cardiac hypertrophy through autophagy in vitro

Hyperbolic Tangent-Type Variant-Parameter and Robust ZNN Solutions for Resolving Time-Variant Sylvester Equation in Preassigned-Time

Experimental Sensing and Density Functional Theory Study of H 2 S and SOF 2 Adsorption on Au‐Modified Graphene

Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy

LINC01287 facilitates proliferation, migration, invasion and EMT of colon cancer cells via miR-4500/MAP3K13 pathway

SLC5A2 mutations, including two novel mutations, responsible for renal glucosuria in Chinese families

Ground-level ozone (O3) pollution and its impacts on vegetation: an attribute to Prof. Evgenios Agathokleous

The effect of methanol fixation on single-cell RNA sequencing data

Correction to: The effect of methanol fixation on single-cell RNA sequencing data

AI-empowered game architecture and application for resource provision and scheduling in multi-clouds

The deconstruction of emotional identity of recreation for ethnic cultural heritage in the geo-cultural perspective: a fuzzy set qualitative comparative analysis on Wuqiang new year paintings

Role of periostin in ECRS

BMAL1 plays a critical role in the protection against cardiac hypertrophy through autophagy in vitro

Hyperbolic Tangent-Type Variant-Parameter and Robust ZNN Solutions for Resolving Time-Variant Sylvester Equation in Preassigned-Time

Experimental Sensing and Density Functional Theory Study of H 2 S and SOF 2 Adsorption on Au‐Modified Graphene

Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy

LINC01287 facilitates proliferation, migration, invasion and EMT of colon cancer cells via miR-4500/MAP3K13 pathway

SLC5A2 mutations, including two novel mutations, responsible for renal glucosuria in Chinese families

Cultural heritage institutions wishing to register will find more information here.

Fields marked * need to be filled in.

Username*

Please enter your username

Email*

Please enter your email address

Please do not fill this field

First name

Last name

Password*

Please enter your password

Confirm password*

Please enter the same password

I have read the terms of use and the privacy policy for the collection of personal data and accept them. *

This field is required.

I would like to subscribe to the newsletter of the Deutsche Digitale Bibliothek. See newsletter subscription info.

Account created

Your "My DDB" account has been successfully created. Before you can log in to your account, you must click the confirmation link in the message we just sent to the email address you provided.

Electric Conductivity on Aligned Nanofibers Facilitates the Transdifferentiation of Mesenchymal Stem Cells into Schwann Cells and Regeneration of Injured Peripheral Nerve

Object Details

References and Relationships

Contributors, Places and Time

Further information

Data provider

Associated

Other Objects (12)

Ground-level ozone (O3) pollution and its impacts on vegetation: an attribute to Prof. Evgenios Agathokleous

The effect of methanol fixation on single-cell RNA sequencing data

Correction to: The effect of methanol fixation on single-cell RNA sequencing data

AI-empowered game architecture and application for resource provision and scheduling in multi-clouds

The deconstruction of emotional identity of recreation for ethnic cultural heritage in the geo-cultural perspective: a fuzzy set qualitative comparative analysis on Wuqiang new year paintings

Role of periostin in ECRS

BMAL1 plays a critical role in the protection against cardiac hypertrophy through autophagy in vitro

Hyperbolic Tangent-Type Variant-Parameter and Robust ZNN Solutions for Resolving Time-Variant Sylvester Equation in Preassigned-Time

Experimental Sensing and Density Functional Theory Study of H 2 S and SOF 2 Adsorption on Au‐Modified Graphene

Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy

LINC01287 facilitates proliferation, migration, invasion and EMT of colon cancer cells via miR-4500/MAP3K13 pathway

SLC5A2 mutations, including two novel mutations, responsible for renal glucosuria in Chinese families

Ground-level ozone (O3) pollution and its impacts on vegetation: an attribute to Prof. Evgenios Agathokleous

The effect of methanol fixation on single-cell RNA sequencing data

Correction to: The effect of methanol fixation on single-cell RNA sequencing data

AI-empowered game architecture and application for resource provision and scheduling in multi-clouds

The deconstruction of emotional identity of recreation for ethnic cultural heritage in the geo-cultural perspective: a fuzzy set qualitative comparative analysis on Wuqiang new year paintings

Role of periostin in ECRS

BMAL1 plays a critical role in the protection against cardiac hypertrophy through autophagy in vitro

Hyperbolic Tangent-Type Variant-Parameter and Robust ZNN Solutions for Resolving Time-Variant Sylvester Equation in Preassigned-Time

Experimental Sensing and Density Functional Theory Study of H 2 S and SOF 2 Adsorption on Au‐Modified Graphene

Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy

LINC01287 facilitates proliferation, migration, invasion and EMT of colon cancer cells via miR-4500/MAP3K13 pathway

SLC5A2 mutations, including two novel mutations, responsible for renal glucosuria in Chinese families

Ground-level ozone (O3) pollution and its impacts on vegetation: an attribute to Prof. Evgenios Agathokleous

The effect of methanol fixation on single-cell RNA sequencing data

Correction to: The effect of methanol fixation on single-cell RNA sequencing data

AI-empowered game architecture and application for resource provision and scheduling in multi-clouds

The deconstruction of emotional identity of recreation for ethnic cultural heritage in the geo-cultural perspective: a fuzzy set qualitative comparative analysis on Wuqiang new year paintings

Role of periostin in ECRS

BMAL1 plays a critical role in the protection against cardiac hypertrophy through autophagy in vitro

Hyperbolic Tangent-Type Variant-Parameter and Robust ZNN Solutions for Resolving Time-Variant Sylvester Equation in Preassigned-Time

Experimental Sensing and Density Functional Theory Study of H 2 S and SOF 2 Adsorption on Au‐Modified Graphene

Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy

LINC01287 facilitates proliferation, migration, invasion and EMT of colon cancer cells via miR-4500/MAP3K13 pathway

SLC5A2 mutations, including two novel mutations, responsible for renal glucosuria in Chinese families

Related objects

Reset password