Optically Programmable Living Microrouter in Vivo
Abstract: With high reconfigurability and swarming intelligence, programmable medical micromachines (PMMs) represent a revolution in microrobots for executing complex coordinated tasks, especially for dynamic routing of various targets along their respective routes. However, it is difficult to achieve a biocompatible implantation into the body due to their exogenous building blocks. Herein, a living microrouter based on an organic integration of endogenous red blood cells (RBCs), programmable scanning optical tweezers and flexible optofluidic strategy is reported. By harvesting energy from a designed optical force landscape, five RBCs are optically rotated in a controlled velocity and direction, under which, a specific actuation flow is achieved to exert the well‐defined hydrodynamic forces on various biological targets, thus enabling a selective routing by integrating three successive functions, i.e., dynamic input, inner processing, and controlled output. Benefited from the optofluidic manipulation, various blood cells, such as the platelets and white blood cells, are transported toward the damaged vessel and cell debris for the dynamic hemostasis and targeted clearance, respectively. Moreover, the microrouter enables a precise transport of nanodrugs for active and targeted delivery in a large quantity. The proposed RBC microrouter might provide a biocompatible medical platform for cell separation, drug delivery, and immunotherapy.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Optically Programmable Living Microrouter in Vivo ; day:25 ; month:09 ; year:2023 ; extent:12
Advanced science ; (25.09.2023) (gesamt 12)
- Creator
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Liu, Xiaoshuai
Wu, Huaying
Wu, Shuai
Qin, Haifeng
Zhang, Tiange
Lin, Yufeng
Zheng, Xianchuang
Li, Baojun
- DOI
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10.1002/advs.202304103
- URN
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urn:nbn:de:101:1-2023092615141540404023
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:57 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Liu, Xiaoshuai
- Wu, Huaying
- Wu, Shuai
- Qin, Haifeng
- Zhang, Tiange
- Lin, Yufeng
- Zheng, Xianchuang
- Li, Baojun
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