Investigations into Simplified Analogues of the Herbicidal Natural Product (+)‐Cornexistin
Abstract: We report the design, synthesis and biological evaluation of simplified analogues of the herbicidal natural product (+)‐cornexistin. Guided by an X‐Ray co‐crystal structure of cornexistin bound to transketolase from Zea mays, we attempted to identify the key interactions that are necessary for cornexistin to maintain its herbicidal profile. This resulted in the preparation of three novel analogues investigating the importance of substituents that are located on the nine‐membered ring of cornexistin. One analogue maintained a good level of biological activity and could provide researchers insights in how to further optimize the structure of cornexistin for commercialization in the future.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Investigations into Simplified Analogues of the Herbicidal Natural Product (+)‐Cornexistin ; day:23 ; month:05 ; year:2023 ; extent:9
Chemistry - a European journal ; (23.05.2023) (gesamt 9)
- Creator
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Steinborn, Christian
Tancredi, Aldo
Habiger, Christoph
Diederich, Christina
Kramer, Jan
Reingruber, Anna M.
Laber, Bernd
Freigang, Jörg
Lange, Gudrun
Schmutzler, Dirk
Machettira, Anu
Besong, Gilbert
Magauer, Thomas
Barber, David M.
- DOI
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10.1002/chem.202300199
- URN
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urn:nbn:de:101:1-2023052315203980008393
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 11:02 AM CEST
Data provider
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Associated
- Steinborn, Christian
- Tancredi, Aldo
- Habiger, Christoph
- Diederich, Christina
- Kramer, Jan
- Reingruber, Anna M.
- Laber, Bernd
- Freigang, Jörg
- Lange, Gudrun
- Schmutzler, Dirk
- Machettira, Anu
- Besong, Gilbert
- Magauer, Thomas
- Barber, David M.
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