Queuosine‐tRNA promotes sex‐dependent learning and memory formation by maintaining codon‐biased translation elongation speed
Abstract: Queuosine (Q) is a modified nucleoside at the wobble position of specific tRNAs. In mammals, queuosinylation is facilitated by queuine uptake from the gut microbiota and is introduced into tRNA by the QTRT1‐QTRT2 enzyme complex. By establishing a Qtrt1 knockout mouse model, we discovered that the loss of Q‐tRNA leads to learning and memory deficits. Ribo‐Seq analysis in the hippocampus of Qtrt1‐deficient mice revealed not only stalling of ribosomes on Q‐decoded codons, but also a global imbalance in translation elongation speed between codons that engage in weak and strong interactions with their cognate anticodons. While Q‐dependent molecular and behavioral phenotypes were identified in both sexes, female mice were affected more severely than males. Proteomics analysis confirmed deregulation of synaptogenesis and neuronal morphology. Together, our findings provide a link between tRNA modification and brain functions and reveal an unexpected role of protein synthesis in sex‐dependent cognitive performance.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Queuosine‐tRNA promotes sex‐dependent learning and memory formation by maintaining codon‐biased translation elongation speed ; day:23 ; month:08 ; year:2023 ; extent:28
The EMBO journal / European Molecular Biology Organization ; (23.08.2023) (gesamt 28)
- Creator
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Cirzi, Cansu
Dyckow, Julia
Legrand, Carine
Schott, Johanna
Guo, Wei
Perez Hernandez, Daniel
Hisaoka, Miharu
Parlato, Rosanna
Pitzer, Claudia
van der Hoeven, Franciscus
Dittmar, Gunnar
Helm, Mark
Stoecklin, Georg
Schirmer, Lucas
Lyko, Frank
Tuorto, Francesca
- DOI
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10.15252/embj.2022112507
- URN
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urn:nbn:de:101:1-2023082315211775372666
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:44 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Cirzi, Cansu
- Dyckow, Julia
- Legrand, Carine
- Schott, Johanna
- Guo, Wei
- Perez Hernandez, Daniel
- Hisaoka, Miharu
- Parlato, Rosanna
- Pitzer, Claudia
- van der Hoeven, Franciscus
- Dittmar, Gunnar
- Helm, Mark
- Stoecklin, Georg
- Schirmer, Lucas
- Lyko, Frank
- Tuorto, Francesca
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