Reference on copy number variations in pleomorphic xanthoastrocytoma: Implications for diagnostic approach
Abstract: Pleomorphic xanthoastrocytoma (PXA) poses a diagnostic challenge. The present study relies on methylation-based predictions and focuses on copy number variations (CNV) in PXA. We identified 551 tumors from patients having received the histologic diagnosis or differential diagnosis pleomorphic xanthoastrocytoma (PXA) uploaded to the web page www.molecularneuropathology.org. Of these 551 tumors, 165 received the prediction “methylation class (anaplastic) pleomorphic xanthoastrocytoma” with a calibrated score >=0.9 by the brain tumor classifier version v12.8 and, therefore, were defined the PXA reference set designated mcPXAref. In addition to these 165 mcPXAref, 767 other tumors received the prediction mcPXA with a calibrated score >=0.9 but without a histological PXA diagnosis. The total number of individual tumors predicted by histology and/or by methylome based classification as PXA, mcPXA or both was 1318, and these were designated the study cohort. The selection of a control coh.... https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/5156
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Reference on copy number variations in pleomorphic xanthoastrocytoma: Implications for diagnostic approach ; volume:4 ; year:2023
Free Neuropathology ; 4 (2023)
- Urheber
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Reuss, David
Schrimpf, Daniel
Stichel, Damian
Ebrahimi, Azadeh
Dampier, Chris
Aldape, Kenneth
Snuderl, Matija
Capper, David
Sill, Martin
Jones, David T.W
Pfister, Stefan M.
Felix, Sahm
Deimling, Andreas von
- DOI
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10.17879/freeneuropathology-2023-5156
- URN
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urn:nbn:de:hbz:6:3-freeneuropathology-2023-53105
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:35 MESZ
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Beteiligte
- Reuss, David
- Schrimpf, Daniel
- Stichel, Damian
- Ebrahimi, Azadeh
- Dampier, Chris
- Aldape, Kenneth
- Snuderl, Matija
- Capper, David
- Sill, Martin
- Jones, David T.W
- Pfister, Stefan M.
- Felix, Sahm
- Deimling, Andreas von
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