O papel do ácido tranexâmico na prevenção e gerenciamento da perda de sangue na artroplastia total de articulação

Abstract: Objective To collect data on the role played by tranexamic acid in the prevention and management of blood loss in patients undergoing total hip arthroplasty and total knee arthroplasty. Methods In the present prospective, comparative study, 30 patients undergoing total hip arthroplasty (THA) or total knee arthroplasty (TKA) were randomly allocated into 1 of 2 groups with 15 patients each. Tranexamic acid was administered by intravenous and topical routes in the study group, but it was not administered in the control group. Preoperative blood parameters, intraoperative and postoperative blood loss, and need for blood transfusion were noted. Statistical analysis was performed using the chi-squared test and the independent t-test. Results The study group had statistically significant higher postoperative hemoglobin values (p = 0.03), less difference between pre and postoperative hemoglobin value (p = 0.046), less difference between pre and postoperative packed-cell volume (p = 0.06), less intraoperative measured blood loss (p = 0.015), and less volume of blood collected in the drain (p = 0.0291) compared with the control group. There was also reduced frequency of blood transfusions in the study group (p = 0.0008). Conclusion Tranexamic acid is associated with reduced intra and postoperative blood loss and reduced frequency of blood transfusions in patients undergoing THA/TKA.

Object Details

• Alternative title: The Role of Tranexamic Acid in the Prevention and Management of Blood Loss in Total Joint Arthroplasty
• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Portugiesisch

References and Relationships

• Bibliographic citation: O papel do ácido tranexâmico na prevenção e gerenciamento da perda de sangue na artroplastia total de articulação ; day:25 ; month:10 ; year:2021 ; Revista Brasileira de ortopedia ; (25.10.2021)

Contributors, Places and Time

• Contributor: Thammaiah, Adarsh ; Gajapurada, Siddalingamurthy ; Nandakumar, Sanjana ; Sastry, Purushotham ; Mruthyunjaya, Mruthyunjaya

Further information

• DOI: 10.1055/s-0041-1729933
• URN: urn:nbn:de:101:1-2021120911472570872184
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:36 AM CEST