Oxytocin Protects Nigrostriatal Dopamine Signal via Activating GABAergic Circuit in the MPTP‐Induced Parkinson's Disease Model

zu Verbundenen Objekten

Abstract: The most pronounced neuropathological feature of Parkinson's disease (PD) is the loss of dopamine (DA) neurons in the substantia nigra compacta (SNc), which depletes striatal DA. Hypothalamic oxytocin is found to be reduced in PD patients and closely interacts with the DA system, but the role of oxytocin in PD remains unclear. Here, the disturbances of endogenous oxytocin level and the substantia nigra (SN) oxytocin receptor expression in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced PD mouse model is observed, correlated with the striatal tyrosine hydroxylase (TH) expression reduction. Killing/silencing hypothalamic oxytocin neurons aggravates the vulnerability of nigrostriatal DA signal to MPTP, whereas elevating oxytocin level by intranasal delivery or microinjecting into the SN promotes the resistance. In addition, knocking out SN oxytocin receptors induces the time‐dependent reductions of SNc DA neurons, striatal TH expression, and striatal DA level by increasing neuronal excitotoxicity. These results further uncover that oxytocin dampens the excitatory synaptic inputs onto DA neurons via activating oxytocin receptor‐expressed SN GABA neurons, which target GABA (B) receptors expressed in SNc DA neuron‐projecting glutamatergic axons, to reduce excitotoxicity. Thus, besides the well‐known prosocial effect, oxytocin acts as a key endogenous factor in protecting the nigrostriatal DA system.

Standort: Deutsche Nationalbibliothek Frankfurt am Main

Umfang: Online-Ressource

Sprache: Englisch

Erschienen in: Oxytocin Protects Nigrostriatal Dopamine Signal via Activating GABAergic Circuit in the MPTP‐Induced Parkinson's Disease Model ; day:05 ; month:08 ; year:2024 ; extent:20
Advanced science ; (05.08.2024) (gesamt 20)

Urheber: Wang, Yurong
Xu, Hao
Chen, Saiyong
Chen, Junhao
Zheng, Qimeng
Ma, Yuanyuan
Zhao, Xinru
Shi, Ying
Xiao, Lei

DOI: 10.1002/advs.202310244

URN: urn:nbn:de:101:1-2408051425532.376053036319

Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Letzte Aktualisierung: 14.08.2025, 11:02 MESZ

Datenpartner

Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.

Original beim Datenpartner anzeigen

Beteiligte

Wang, Yurong
Xu, Hao
Chen, Saiyong
Chen, Junhao
Zheng, Qimeng
Ma, Yuanyuan
Zhao, Xinru
Shi, Ying
Xiao, Lei

Ähnliche Objekte (12)

Decoherence and thermalization of Unruh-DeWitt detector in arbitrary dimensions

Energy change and Landauer’s principle in the interaction between qubit and quantum field theory

Distinguishing pure and thermal states by Landauer’s principle in open systems

The Anode Materials for Lithium‐Ion and Sodium‐Ion Batteries Based on Conversion Reactions: a Review

Black hole evaporation in Hořava–Lifshitz gravity

Semantic Interpretation for Convolutional Neural Networks: What Makes a Cat a Cat?

Semantic Interpretation for Convolutional Neural Networks: What Makes a Cat a Cat? (Adv. Sci. 35/2022)

Copper-Catalyzed Synthesis of 1,2,4-Triazoles via Sequential Coupling and Aerobic Oxidative Dehydrogenation of Amidines

Aufsatzsammlung

Micro-mesoporous metallosilicates : synthesis, characterization, and catalytic applications

Causal associations of remnant cholesterol with cardiometabolic diseases and risk factors: a mendelian randomization analysis

$Hawking evaporation of Einstein–Gauss–Bonnet AdS black holes in $$D\geqslant 4$$ D ⩾ 4 dimensions$

Hawking evaporation of Einstein–Gauss–Bonnet AdS black holes in $$D\geqslant 4$$ D ⩾ 4 dimensions

$Implication of the observed $$e^+}e^{-}\rightarrow p{\bar{p}}\pi ^0$$ e + e - → p p ¯ π 0 for studying the $$p{\bar{p}}\rightarrow \psi (3770)\pi ^0$$ p p ¯ → ψ ( 3770 ) π 0 process$

Implication of the observed $$e^+}e^{-}\rightarrow p{\bar{p}}\pi ^0$$ e + e - → p p ¯ π 0 for studying the $$p{\bar{p}}\rightarrow \psi (3770)\pi ^0$$ p p ¯ → ψ ( 3770 ) π 0 process

Decoherence and thermalization of Unruh-DeWitt detector in arbitrary dimensions

Energy change and Landauer’s principle in the interaction between qubit and quantum field theory

Distinguishing pure and thermal states by Landauer’s principle in open systems

The Anode Materials for Lithium‐Ion and Sodium‐Ion Batteries Based on Conversion Reactions: a Review

Black hole evaporation in Hořava–Lifshitz gravity

Semantic Interpretation for Convolutional Neural Networks: What Makes a Cat a Cat?

Semantic Interpretation for Convolutional Neural Networks: What Makes a Cat a Cat? (Adv. Sci. 35/2022)

Copper-Catalyzed Synthesis of 1,2,4-Triazoles via Sequential Coupling and Aerobic Oxidative Dehydrogenation of Amidines

Aufsatzsammlung

Micro-mesoporous metallosilicates : synthesis, characterization, and catalytic applications

Causal associations of remnant cholesterol with cardiometabolic diseases and risk factors: a mendelian randomization analysis

$Hawking evaporation of Einstein–Gauss–Bonnet AdS black holes in $$D\geqslant 4$$ D ⩾ 4 dimensions$

Hawking evaporation of Einstein–Gauss–Bonnet AdS black holes in $$D\geqslant 4$$ D ⩾ 4 dimensions

$Implication of the observed $$e^+}e^{-}\rightarrow p{\bar{p}}\pi ^0$$ e + e - → p p ¯ π 0 for studying the $$p{\bar{p}}\rightarrow \psi (3770)\pi ^0$$ p p ¯ → ψ ( 3770 ) π 0 process$

Implication of the observed $$e^+}e^{-}\rightarrow p{\bar{p}}\pi ^0$$ e + e - → p p ¯ π 0 for studying the $$p{\bar{p}}\rightarrow \psi (3770)\pi ^0$$ p p ¯ → ψ ( 3770 ) π 0 process

Decoherence and thermalization of Unruh-DeWitt detector in arbitrary dimensions

Energy change and Landauer’s principle in the interaction between qubit and quantum field theory

Distinguishing pure and thermal states by Landauer’s principle in open systems

The Anode Materials for Lithium‐Ion and Sodium‐Ion Batteries Based on Conversion Reactions: a Review

Black hole evaporation in Hořava–Lifshitz gravity

Semantic Interpretation for Convolutional Neural Networks: What Makes a Cat a Cat?

Semantic Interpretation for Convolutional Neural Networks: What Makes a Cat a Cat? (Adv. Sci. 35/2022)

Copper-Catalyzed Synthesis of 1,2,4-Triazoles via Sequential Coupling and Aerobic Oxidative Dehydrogenation of Amidines

Aufsatzsammlung

Micro-mesoporous metallosilicates : synthesis, characterization, and catalytic applications

Causal associations of remnant cholesterol with cardiometabolic diseases and risk factors: a mendelian randomization analysis

$Hawking evaporation of Einstein–Gauss–Bonnet AdS black holes in $$D\geqslant 4$$ D ⩾ 4 dimensions$

Hawking evaporation of Einstein–Gauss–Bonnet AdS black holes in $$D\geqslant 4$$ D ⩾ 4 dimensions

$Implication of the observed $$e^+}e^{-}\rightarrow p{\bar{p}}\pi ^0$$ e + e - → p p ¯ π 0 for studying the $$p{\bar{p}}\rightarrow \psi (3770)\pi ^0$$ p p ¯ → ψ ( 3770 ) π 0 process$

Implication of the observed $$e^+}e^{-}\rightarrow p{\bar{p}}\pi ^0$$ e + e - → p p ¯ π 0 for studying the $$p{\bar{p}}\rightarrow \psi (3770)\pi ^0$$ p p ¯ → ψ ( 3770 ) π 0 process

Informationen zur Registrierung von Kultur- und Wissenseinrichtungen finden Sie hier.

Felder mit * müssen ausgefüllt werden.

Benutzername*

Bitte geben Sie Ihren Benutzernamen ein

E-Mail*

Bitte geben Sie Ihre E-Mail ein

Bitte füllen Sie dieses Feld nicht aus

Vorname

Nachname

Passwort*

Bitte geben Sie Ihr Passwort ein

Passwort bestätigen*

Bitte geben Sie das gleiche Passwort ein

Ich habe die Nutzungsbedingungen und die Datenschutzerklärung zur Erhebung persönlicher Daten gelesen und stimme ihnen zu. *

Dieses Feld ist ein Pflichtfeld.

Ich möchte den Newsletter der Deutschen Digitalen Bibliothek abonnieren. Siehe Informationen zum Newsletter-Abonnement.

Benutzerkonto angelegt

Ihr „Meine DDB“-Konto wurde erfolgreich angelegt. Bevor Sie sich in Ihrem Konto anmelden können, müssen Sie auf den Bestätigungslink in der Nachricht klicken, die wir gerade an die von Ihnen angegebene E-Mail-Adresse geschickt haben

Oxytocin Protects Nigrostriatal Dopamine Signal via Activating GABAergic Circuit in the MPTP‐Induced Parkinson's Disease Model

Angaben zum Objekt

Verweise und Beziehungen

Beteiligte, Orts- und Zeitangaben

Weitere Informationen

Datenpartner

Beteiligte

Ähnliche Objekte (12)

Decoherence and thermalization of Unruh-DeWitt detector in arbitrary dimensions

Energy change and Landauer’s principle in the interaction between qubit and quantum field theory

Distinguishing pure and thermal states by Landauer’s principle in open systems

The Anode Materials for Lithium‐Ion and Sodium‐Ion Batteries Based on Conversion Reactions: a Review

Black hole evaporation in Hořava–Lifshitz gravity

Semantic Interpretation for Convolutional Neural Networks: What Makes a Cat a Cat?

Semantic Interpretation for Convolutional Neural Networks: What Makes a Cat a Cat? (Adv. Sci. 35/2022)

Copper-Catalyzed Synthesis of 1,2,4-Triazoles via Sequential Coupling and Aerobic Oxidative Dehydrogenation of Amidines

Micro-mesoporous metallosilicates : synthesis, characterization, and catalytic applications

Causal associations of remnant cholesterol with cardiometabolic diseases and risk factors: a mendelian randomization analysis

Hawking evaporation of Einstein–Gauss–Bonnet AdS black holes in $$D\geqslant 4$$ D ⩾ 4 dimensions

Implication of the observed $$e^+}e^{-}\rightarrow p{\bar{p}}\pi ^0$$ e + e - → p p ¯ π 0 for studying the $$p{\bar{p}}\rightarrow \psi (3770)\pi ^0$$ p p ¯ → ψ ( 3770 ) π 0 process

Decoherence and thermalization of Unruh-DeWitt detector in arbitrary dimensions

Energy change and Landauer’s principle in the interaction between qubit and quantum field theory

Distinguishing pure and thermal states by Landauer’s principle in open systems

The Anode Materials for Lithium‐Ion and Sodium‐Ion Batteries Based on Conversion Reactions: a Review

Black hole evaporation in Hořava–Lifshitz gravity

Semantic Interpretation for Convolutional Neural Networks: What Makes a Cat a Cat?

Semantic Interpretation for Convolutional Neural Networks: What Makes a Cat a Cat? (Adv. Sci. 35/2022)

Copper-Catalyzed Synthesis of 1,2,4-Triazoles via Sequential Coupling and Aerobic Oxidative Dehydrogenation of Amidines

Micro-mesoporous metallosilicates : synthesis, characterization, and catalytic applications

Causal associations of remnant cholesterol with cardiometabolic diseases and risk factors: a mendelian randomization analysis

Hawking evaporation of Einstein–Gauss–Bonnet AdS black holes in $$D\geqslant 4$$ D ⩾ 4 dimensions

Implication of the observed $$e^+}e^{-}\rightarrow p{\bar{p}}\pi ^0$$ e + e - → p p ¯ π 0 for studying the $$p{\bar{p}}\rightarrow \psi (3770)\pi ^0$$ p p ¯ → ψ ( 3770 ) π 0 process

Decoherence and thermalization of Unruh-DeWitt detector in arbitrary dimensions

Energy change and Landauer’s principle in the interaction between qubit and quantum field theory

Distinguishing pure and thermal states by Landauer’s principle in open systems

The Anode Materials for Lithium‐Ion and Sodium‐Ion Batteries Based on Conversion Reactions: a Review

Black hole evaporation in Hořava–Lifshitz gravity

Semantic Interpretation for Convolutional Neural Networks: What Makes a Cat a Cat?

Semantic Interpretation for Convolutional Neural Networks: What Makes a Cat a Cat? (Adv. Sci. 35/2022)

Copper-Catalyzed Synthesis of 1,2,4-Triazoles via Sequential Coupling and Aerobic Oxidative Dehydrogenation of Amidines

Micro-mesoporous metallosilicates : synthesis, characterization, and catalytic applications

Causal associations of remnant cholesterol with cardiometabolic diseases and risk factors: a mendelian randomization analysis

Hawking evaporation of Einstein–Gauss–Bonnet AdS black holes in $$D\geqslant 4$$ D ⩾ 4 dimensions

Implication of the observed $$e^+}e^{-}\rightarrow p{\bar{p}}\pi ^0$$ e + e - → p p ¯ π 0 for studying the $$p{\bar{p}}\rightarrow \psi (3770)\pi ^0$$ p p ¯ → ψ ( 3770 ) π 0 process

Verbundene Objekte

Passwort zurücksetzen