Selective and Stepwise Functionalization of the Pyridazine Scaffold by Using Thio‐Substituted Pyridazine Building Blocks

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Abstract: We described a regioselective tri‐ and tetra‐functionalization of the pyridazine scaffold using two readily available building blocks: 3‐alkylthio‐6‐chloropyridazine and 3,4‐bis (methylthio)‐6‐chloropyridazine by performing selective metalations with TMPMgCl ⋅ LiCl and catalyst‐tuned cross‐coupling reactions with arylzinc halides. Several of the resulting pyridazines were converted into more elaborated N‐heterocycles such as thieno[2,3‐c]pyridazines and 1H‐pyrazolo[3,4‐c]pyridazines.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Selective and Stepwise Functionalization of the Pyridazine Scaffold by Using Thio‐Substituted Pyridazine Building Blocks ; day:03 ; month:10 ; year:2023 ; extent:8
Chemistry - a European journal ; (03.10.2023) (gesamt 8)

Creator: Hamze, Clémence
Brossier, Julie
Karaghiosoff, Konstantin
Godineau, Edouard
Knochel, Paul

DOI: 10.1002/chem.202302156

URN: urn:nbn:de:101:1-2023100415182306849200

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:47 AM CEST

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Associated

Hamze, Clémence
Brossier, Julie
Karaghiosoff, Konstantin
Godineau, Edouard
Knochel, Paul

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