Management of Antithrombin Deficiency in Pregnancy
Abstract: Antithrombin (AT) deficiency is a high-risk thrombophilia and a rare condition. The risk of venous thromboembolism (VTE) is increased in AT-deficient women during pregnancy and the postpartum period and is especially high in women with a prior history of VTE. A thorough assessment of VTE risk is recommended in pregnant AT-deficient women, comprising the degree and type of AT deficiency, genetic mutations, personal and family history, and additional preexisting or pregnancy-specific risk factors. Due to a lack of adequate study data, there is limited guidance on the management of AT deficiency in pregnancy, including the need for prophylactic anticoagulation, the appropriate dose of low-molecular-weight heparin (LMWH), and the role of AT substitution. LMWH is the medication of choice for the pharmacological prophylaxis and treatment of VTE in pregnancy. Patients with a history of VTE should receive full-dose LMWH during pregnancy and the postpartum period. AT concentrates are a treatment option when anticoagulation is withheld in potentially high-risk events such as childbirth, bleeding, or surgery and in cases of acute VTE despite the use of therapeutic dose anticoagulation. Women with AT deficiency should be counseled at specialized centers for coagulation disorders or vascular medicine, and close cooperation between obstetricians and anesthesiologists is warranted before delivery and during the peripartum period.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Management of Antithrombin Deficiency in Pregnancy ; volume:42 ; number:05 ; year:2022 ; pages:320-329
Hämostaseologie ; 42, Heft 05 (2022), 320-329
- Contributor
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Hart, Christina
Rott, Hannelore
Heimerl, Susanne
Linnemann, Birgit
- DOI
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10.1055/a-1841-0399
- URN
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urn:nbn:de:101:1-2022122210301324806666
- Rights
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Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:27 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Hart, Christina
- Rott, Hannelore
- Heimerl, Susanne
- Linnemann, Birgit
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Comparison of antithrombin activity assays in detection of patients with heparin binding site antithrombin deficiency: systematic review and meta-analysis
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Iodine deficiency in pregnancy
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Hereditary Deficiency of Antithrombin III.
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Reduction of D-dimer levels after therapeutic administration of antithrombin in acquired antithrombin deficiency of severe sepsis
Identification of two point mutations associated with inherited antithrombin deficiency
Thrombosis-related characteristics of pregnant women with antithrombin deficiency, protein C deficiency and protein S deficiency in Japan
Identification and characterization of two SERPINC1 mutations causing congenital antithrombin deficiency
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Iodine deficiency in pregnancy
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