Macromolecular Viral Entry Inhibitors as Broad‐Spectrum First‐Line Antivirals with Activity against SARS‐CoV‐2
Abstract: Inhibitors of viral cell entry based on poly (styrene sulfonate) and its core–shell nanoformulations based on gold nanoparticles are investigated against a panel of viruses, including clinical isolates of SARS‐CoV‐2. Macromolecular inhibitors are shown to exhibit the highly sought‐after broad‐spectrum antiviral activity, which covers most analyzed enveloped viruses and all of the variants of concern for SARS‐CoV‐2 tested. The inhibitory activity is quantified in vitro in appropriate cell culture models and for respiratory viral pathogens (respiratory syncytial virus and SARS‐CoV‐2) in mice. Results of this study comprise a significant step along the translational path of macromolecular inhibitors of virus cell entry, specifically against enveloped respiratory viruses.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Macromolecular Viral Entry Inhibitors as Broad‐Spectrum First‐Line Antivirals with Activity against SARS‐CoV‐2 ; day:11 ; month:05 ; year:2022 ; extent:17
Advanced science ; (11.05.2022) (gesamt 17)
- Creator
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Groß, Rüdiger
Dias Loiola, Lívia Mesquita
Issmail, Leila
Uhlig, Nadja
Eberlein, Valentina
Conzelmann, Carina
Olari, Lia‐Raluca
Rauch, Lena
Lawrenz, Jan
Weil, Tatjana
Müller, Janis A.
Cardoso, Mateus Borba
Gilg, Andrea
Larsson, Olivia
Höglund, Urban
Pålsson, Sandra Axberg
Tvilum, Anna Selch
Løvschall, Kaja Borup
Kristensen, Maria M.
Spetz, Anna‐Lena
Hontonnou, Fortune
Galloux, Marie
Grunwald, Thomas
Zelikin, Alexander N.
Münch, Jan
- DOI
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10.1002/advs.202201378
- URN
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urn:nbn:de:101:1-2022051215014599114661
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:36 AM CEST
Data provider
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Associated
- Groß, Rüdiger
- Dias Loiola, Lívia Mesquita
- Issmail, Leila
- Uhlig, Nadja
- Eberlein, Valentina
- Conzelmann, Carina
- Olari, Lia‐Raluca
- Rauch, Lena
- Lawrenz, Jan
- Weil, Tatjana
- Müller, Janis A.
- Cardoso, Mateus Borba
- Gilg, Andrea
- Larsson, Olivia
- Höglund, Urban
- Pålsson, Sandra Axberg
- Tvilum, Anna Selch
- Løvschall, Kaja Borup
- Kristensen, Maria M.
- Spetz, Anna‐Lena
- Hontonnou, Fortune
- Galloux, Marie
- Grunwald, Thomas
- Zelikin, Alexander N.
- Münch, Jan
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