Role of BAX complexes in apoptosis signaling
Abstract: OMM permeabilization by active BAX and BAK results in release of proteins, such as cytochrome c, from the mitochondrial intermembrane space to the cytosol. Cytochrome c mediates apoptosome formation and, thus, triggers activation of the caspase cascade by activation of the initiator caspase-9. On the one hand, small active BAX complexes were reported to be sufficient for efficient OMM permeabilization and protein release. On the other hand, active BAX was shown to form large oligomeric structures, which protrude into the cytosol. In this study, organization of endogenous BAX into either small complexes and large membrane-associated structures was shown. These results demonstrate, that small mitochondrial BAX complexes are sufficient for OMM permeabiliation and cytochrome c release. OMM permeabilization alone did not induce full caspase activation in absence of large BAX scaffolds. Predominant formation of large BAX scaffolds results in impaired OMM permeabilization, but activation of caspase-9 through direct interactions. Therefore, the apoptosome and BAX scaffolds may present redundant activation platforms for caspase-9, ensuring full caspase activity
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Universität Freiburg, Dissertation, 2022
- Keyword
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Apoptosis
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2021
- Creator
- Contributor
- DOI
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10.6094/UNIFR/194721
- URN
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urn:nbn:de:bsz:25-freidok-1947213
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:36 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
Time of origin
- 2021
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Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis
Role of Bax in resveratrol-induced apoptosis of colorectal carcinoma cells
Regulation and function of BAX in apoptosis
STING dependent BAX-IRF3 signaling results in apoptosis during late-stage Coxiella burnetii infection
Semliki forest virus uses alternative signaling pathways to induce apoptosis in the absence of Bax, Bak
Hypoxia inhibition of camptothecin-induced apoptosis by Bax loss
VDAC2 enables BAX to mediate apoptosis and limit tumor development
Lipid unsaturation promotes BAX and BAK pore activity during apoptosis
Mitochondrial apoptotic foci : relevance of Bax and Drp1 in apoptosis commitment
DRP1 interacts directly with BAX to induce its activation and apoptosis
Characterization of Bax and Drp1 during apoptosis with advanced microscopy techniques
Electromagnetic radiation at 900 MHz induces sperm apoptosis through bcl-2, bax and caspase-3 signaling pathways in rats
Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis
Role of Bax in resveratrol-induced apoptosis of colorectal carcinoma cells
Regulation and function of BAX in apoptosis
STING dependent BAX-IRF3 signaling results in apoptosis during late-stage Coxiella burnetii infection
Semliki forest virus uses alternative signaling pathways to induce apoptosis in the absence of Bax, Bak
Hypoxia inhibition of camptothecin-induced apoptosis by Bax loss
VDAC2 enables BAX to mediate apoptosis and limit tumor development
Lipid unsaturation promotes BAX and BAK pore activity during apoptosis
Mitochondrial apoptotic foci : relevance of Bax and Drp1 in apoptosis commitment
DRP1 interacts directly with BAX to induce its activation and apoptosis
Characterization of Bax and Drp1 during apoptosis with advanced microscopy techniques