Stable Prenucleation Calcium Carbonate Clusters Define Liquid–Liquid Phase Separation
Abstract: Liquid–liquid phase separation (LLPS) is an intermediate step during the precipitation of calcium carbonate, and is assumed to play a key role in biomineralization processes. Here, we have developed a model where ion association thermodynamics in homogeneous phases determine the liquid–liquid miscibility gap of the aqueous calcium carbonate system, verified experimentally using potentiometric titrations, and kinetic studies based on stopped‐flow ATR‐FTIR spectroscopy. The proposed mechanism explains the variable solubilities of solid amorphous calcium carbonates, reconciling previously inconsistent literature values. Accounting for liquid–liquid amorphous polymorphism, the model also provides clues to the mechanism of polymorph selection. It is general and should be tested for systems other than calcium carbonate to provide a new perspective on the physical chemistry of LLPS mechanisms based on stable prenucleation clusters rather than un‐/metastable fluctuations in biomineralization, and beyond.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Stable Prenucleation Calcium Carbonate Clusters Define Liquid–Liquid Phase Separation ; volume:59 ; number:15 ; year:2020 ; pages:6155-6159 ; extent:5
Angewandte Chemie / International edition. International edition ; 59, Heft 15 (2020), 6155-6159 (gesamt 5)
- Urheber
- DOI
-
10.1002/anie.201915350
- URN
-
urn:nbn:de:101:1-2022062212245125981610
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:26 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Avaro, Jonathan T.
- Wolf, Stefan L. P.
- Hauser, Karin
- Gebauer, Denis
Ähnliche Objekte (12)
Stable Pre-nucleation Calcium Carbonate Clusters Define Liquid-Liquid Phase Separation
Generality of liquid precursor phases in gas diffusion-based calcium carbonate synthesis
A Metastable Liquid Precursor Phase of Calcium Carbonate and its Interactions with Polyaspartate
Stable prenucleation calcium carbonate clusters
How Can Additives Control the Early Stages of Mineralisation?
Editorial for Special Issue “Nucleation of Minerals : Precursors, Intermediates and Their Use in Materials Chemistry”
Water Dynamics from THz Spectroscopy Reveal the Locus of a Liquid–Liquid Binodal Limit in Aqueous CaCO<sub>3</sub> Solutions
Bottling Liquid‐Like Minerals for Advanced Materials Synthesis
Liquid Metastable Precursors of Ibuprofen as Aqueous Nucleation Intermediates
Kinetic control of particle-mediated calcium carbonate crystallization
A solvothermal method for synthesizing monolayer protected amorphous calcium carbonate clusters
Synergy of Mg2+ and poly(aspartic acid) in additive-controlled calcium carbonate precipitation
Stable Pre-nucleation Calcium Carbonate Clusters Define Liquid-Liquid Phase Separation
Generality of liquid precursor phases in gas diffusion-based calcium carbonate synthesis
A Metastable Liquid Precursor Phase of Calcium Carbonate and its Interactions with Polyaspartate
Stable prenucleation calcium carbonate clusters
How Can Additives Control the Early Stages of Mineralisation?
Editorial for Special Issue “Nucleation of Minerals : Precursors, Intermediates and Their Use in Materials Chemistry”
Water Dynamics from THz Spectroscopy Reveal the Locus of a Liquid–Liquid Binodal Limit in Aqueous CaCO<sub>3</sub> Solutions
Bottling Liquid‐Like Minerals for Advanced Materials Synthesis
Liquid Metastable Precursors of Ibuprofen as Aqueous Nucleation Intermediates
Kinetic control of particle-mediated calcium carbonate crystallization
A solvothermal method for synthesizing monolayer protected amorphous calcium carbonate clusters
Synergy of Mg2+ and poly(aspartic acid) in additive-controlled calcium carbonate precipitation
Stable Pre-nucleation Calcium Carbonate Clusters Define Liquid-Liquid Phase Separation
Generality of liquid precursor phases in gas diffusion-based calcium carbonate synthesis
A Metastable Liquid Precursor Phase of Calcium Carbonate and its Interactions with Polyaspartate
Stable prenucleation calcium carbonate clusters
How Can Additives Control the Early Stages of Mineralisation?
Editorial for Special Issue “Nucleation of Minerals : Precursors, Intermediates and Their Use in Materials Chemistry”
Water Dynamics from THz Spectroscopy Reveal the Locus of a Liquid–Liquid Binodal Limit in Aqueous CaCO<sub>3</sub> Solutions
Bottling Liquid‐Like Minerals for Advanced Materials Synthesis
Liquid Metastable Precursors of Ibuprofen as Aqueous Nucleation Intermediates
Kinetic control of particle-mediated calcium carbonate crystallization
A solvothermal method for synthesizing monolayer protected amorphous calcium carbonate clusters