Neonatal hyperbilirubinaemia necessitating exchange transfusion due to maternal sickle cell crisis
Background: Pregnancy in women with sickle cell disease (SCD) is associated with a number of fetal complications such as intra-uterine death, intra-uterine growth restriction (IUGR), preterm birth, low birth weight and an increased perinatal mortality and morbidity. Hyperbilirubinaemia necessitating exchange transfusion in an infant of a mother with SCD, to the best of our knowledge, has not been previously described. Case presentation: An infant was delivered at 33 weeks and 5 days of gestation due to a maternal sickle cell crisis. The infant had an unconjugated bilirubin level of 153 μmol/L on admission to the neonatal intensive care unit at 30 min of age. Phototherapy was immediately commenced, intravenous immunoglobulin administered and then a double-volume exchange transfusion was performed. There was, however, no evidence of haemolysis in the infant and the infant’s haemoglobin level remained stable following the exchange. No further exchange transfusions were required. The mother had a high unconjugated bilirubin level (151 μmol/L) prior to delivery. Conclusion: High neonatal unconjugated bilirubin levels necessitating exchange transfusion can occur due to haemolysis in the maternal circulation, in this case due to SCD.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Neonatal hyperbilirubinaemia necessitating exchange transfusion due to maternal sickle cell crisis ; volume:8 ; number:2 ; year:2019 ; extent:4
Case reports in perinatal medicine ; 8, Heft 2 (2019) (gesamt 4)
- Creator
- DOI
-
10.1515/crpm-2019-0030
- URN
-
urn:nbn:de:101:1-2411121540173.726369649810
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:25 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Ambulkar, Hemant
- Bhat, Ravindra
- Greenough, Anne
Other Objects (12)
Neonatal Hemochromatosis: Treatment with Exchange Transfusion and Intravenous Immunoglobulin
Management of Sickle Cell Intrahepatic Cholestasis: An Argument in Favor of Automated Exchange Transfusion
Understanding the risk factors for adverse events during exchange transfusion in neonatal hyperbilirubinemia using explainable artificial intelligence
Retrospective cohort study of neonatal blood transfusion in China
Serial prophylactic exchange blood transfusion in pregnant women with sickle cell disease (TAPS-2): study protocol for a randomised controlled feasibility trial
Neonatal Graves' Disease with Maternal Hypothyroidism
Neonatal manifestations of maternal phencyclidine exposure
The use of partial exchange blood transfusion and anaesthesia in the management of sickle cell disease in a perioperative setting: two case reports
Patient and family experience with chronic transfusion therapy for sickle cell disease: A qualitative study
Can exchange transfusion be replaced by double-LED phototherapy?
Changes in inflammatory proteins following platelet transfusion in a neonatal population
Serial prophylactic exchange blood transfusion in pregnant women with sickle cell disease (TAPS-2): statistical and qualitative analysis plan for a randomised controlled feasibility trial
Neonatal Hemochromatosis: Treatment with Exchange Transfusion and Intravenous Immunoglobulin
Management of Sickle Cell Intrahepatic Cholestasis: An Argument in Favor of Automated Exchange Transfusion
Understanding the risk factors for adverse events during exchange transfusion in neonatal hyperbilirubinemia using explainable artificial intelligence
Retrospective cohort study of neonatal blood transfusion in China
Serial prophylactic exchange blood transfusion in pregnant women with sickle cell disease (TAPS-2): study protocol for a randomised controlled feasibility trial
Neonatal Graves' Disease with Maternal Hypothyroidism
Neonatal manifestations of maternal phencyclidine exposure
The use of partial exchange blood transfusion and anaesthesia in the management of sickle cell disease in a perioperative setting: two case reports
Patient and family experience with chronic transfusion therapy for sickle cell disease: A qualitative study
Can exchange transfusion be replaced by double-LED phototherapy?
Changes in inflammatory proteins following platelet transfusion in a neonatal population
Serial prophylactic exchange blood transfusion in pregnant women with sickle cell disease (TAPS-2): statistical and qualitative analysis plan for a randomised controlled feasibility trial
Neonatal Hemochromatosis: Treatment with Exchange Transfusion and Intravenous Immunoglobulin
Management of Sickle Cell Intrahepatic Cholestasis: An Argument in Favor of Automated Exchange Transfusion
Understanding the risk factors for adverse events during exchange transfusion in neonatal hyperbilirubinemia using explainable artificial intelligence
Retrospective cohort study of neonatal blood transfusion in China
Serial prophylactic exchange blood transfusion in pregnant women with sickle cell disease (TAPS-2): study protocol for a randomised controlled feasibility trial
Neonatal Graves' Disease with Maternal Hypothyroidism
Neonatal manifestations of maternal phencyclidine exposure
The use of partial exchange blood transfusion and anaesthesia in the management of sickle cell disease in a perioperative setting: two case reports
Patient and family experience with chronic transfusion therapy for sickle cell disease: A qualitative study
Can exchange transfusion be replaced by double-LED phototherapy?
Changes in inflammatory proteins following platelet transfusion in a neonatal population