Primary Cilia as Signaling Hubs in Health and Disease
Abstract: Primary cilia detect extracellular cues and transduce these signals into cells to regulate proliferation, migration, and differentiation. Here, the function of primary cilia as signaling hubs of growth factors and morphogens is in focus. First, the molecular mechanisms regulating the assembly and disassembly of primary cilia are described. Then, the role of primary cilia in mediating growth factor and morphogen signaling to maintain human health and the potential mechanisms by which defects in these pathways contribute to human diseases, such as ciliopathy, obesity, and cancer are described. Furthermore, a novel signaling pathway by which certain growth factors stimulate cell proliferation through suppression of ciliogenesis is also described, suggesting novel therapeutic targets in cancer.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Primary Cilia as Signaling Hubs in Health and Disease ; volume:6 ; number:1 ; year:2019 ; extent:14
Advanced science ; 6, Heft 1 (2019) (gesamt 14)
- Creator
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Nishimura, Yuhei
Kasahara, Kousuke
Shiromizu, Takashi
Watanabe, Masatoshi
Inagaki, Masaki
- DOI
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10.1002/advs.201801138
- URN
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urn:nbn:de:101:1-2022071711404093099478
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:34 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Nishimura, Yuhei
- Kasahara, Kousuke
- Shiromizu, Takashi
- Watanabe, Masatoshi
- Inagaki, Masaki
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Mechanical behavior of primary cilia
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Primary cilia utilize glycoprotein-dependent adhesion mechanisms to stabilize long-lasting cilia-cilia contacts
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Amyloid-β interrupts canonical Sonic hedgehog signaling by distorting primary cilia structure
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Primary cilia suppress Ripk3-mediated necroptosis
Primary cilia promote the differentiation of human neurons through the WNT signaling pathway