Metabolically Active, Fully Hydrolysable Polymersomes

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Abstract: The synthesis and aqueous self‐assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether‐substituted epoxide (hydrophile). They self‐assemble into biodegradable polymersomes capable of entering cells. Their degradation products are bioactive, giving rise to differentiated cellular responses inducing stromal cell proliferation and macrophage apoptosis. Both effects emerge only when the copolymers enter cells as polymersomes and their magnitudes are size dependent.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Metabolically Active, Fully Hydrolysable Polymersomes ; volume:131 ; number:14 ; year:2019 ; pages:4629-4634 ; extent:6
Angewandte Chemie ; 131, Heft 14 (2019), 4629-4634 (gesamt 6)

Creator: Zhu, Yunqing
Poma, Alessandro
Rizzello, Loris
Gouveia, Virginia M.
Ruiz‐Perez, Lorena
Battaglia, Giuseppe
Williams, Charlotte K.

DOI: 10.1002/ange.201814320

URN: urn:nbn:de:101:1-2022081206394853376593

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:34 AM CEST

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Associated

Zhu, Yunqing
Poma, Alessandro
Rizzello, Loris
Gouveia, Virginia M.
Ruiz‐Perez, Lorena
Battaglia, Giuseppe
Williams, Charlotte K.

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