Stimulus‐Responsive Copper Complex Nanoparticles Induce Cuproptosis for Augmented Cancer Immunotherapy
Abstract: Cuproptosis, an emerging form of programmed cell death, has received tremendous attention in cancer therapy. However, the efficacy of cuproptosis remains limited by the poor delivery efficiency of copper ion carriers. Herein, copper complex nanoparticles (denoted as Cu (I) NP) are developed that can efficiently deliver copper complex into cancer cells to induce cuproptosis. Cu (I) NP demonstrate stimulus‐responsive release of copper complexes, which results in mitochondrial dysfunction and promotes the aggregation of lipoylated dihydrolipoamide S‐acetyltransferase (DLAT), leading to cuproptosis. Notably, Cu (I) NP not only induce cuproptosis, but also elicit robust immune responses to suppress tumor growth. Overall, this study provides a promising strategy for cuproptosis‐based cancer therapy.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Stimulus‐Responsive Copper Complex Nanoparticles Induce Cuproptosis for Augmented Cancer Immunotherapy ; day:25 ; month:01 ; year:2024 ; extent:12
Advanced science ; (25.01.2024) (gesamt 12)
- Creator
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Hu, Fuzhen
Huang, Jia
Bing, Tiejun
Mou, Wenlong
Li, Duo
Zhang, Hanchen
Chen, Yang
Jin, Qionghua
Yu, Yingjie
Yang, Zhiying
- DOI
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10.1002/advs.202309388
- URN
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urn:nbn:de:101:1-2024012514351937963479
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:34 AM CEST
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Associated
- Hu, Fuzhen
- Huang, Jia
- Bing, Tiejun
- Mou, Wenlong
- Li, Duo
- Zhang, Hanchen
- Chen, Yang
- Jin, Qionghua
- Yu, Yingjie
- Yang, Zhiying
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