Motor versus Psychomotor? Deciphering the Neural Source of Psychomotor Retardation in Depression

Abstract: Major depressive disorder (MDD) is characterized by psychomotor retardation whose underlying neural source remains unclear. Psychomotor retardation may either be related to a motor source like the motor cortex or, alternatively, to a psychomotor source with neural changes outside motor regions, like input regions such as visual cortex. These two alternative hypotheses in main (n = 41) and replication (n = 18) MDD samples using 7 Tesla MRI are investigated. Analyzing both global and local connectivity in primary motor cortex (BA4), motor network and middle temporal visual cortex complex (MT+), the main findings in MDD are: 1) Reduced local and global synchronization and increased local‐to‐global output in motor regions, which do not correlate with psychomotor retardation, though. 2) Reduced local‐to‐local BA4 – MT+ functional connectivity (FC) which correlates with psychomotor retardation. 3) Reduced global synchronization and increased local‐to‐global output in MT+ which relate to psychomotor retardation. 4) Reduced variability in the psychophysical measures of MT+ based motion perception which relates to psychomotor retardation. Together, it is shown that visual cortex MT+ and its relation to motor cortex play a key role in mediating psychomotor retardation. This supports psychomotor over motor hypothesis about the neural source of psychomotor retardation in MDD.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Motor versus Psychomotor? Deciphering the Neural Source of Psychomotor Retardation in Depression ; day:29 ; month:08 ; year:2024 ; extent:13 ; Advanced science ; (29.08.2024) (gesamt 13)

Beteiligte, Orts- und Zeitangaben

• Urheber: Song, Xue Mei ; Liu, Dong‐Yu ; Hirjak, Dusan ; Hu, Xi‐Wen ; Han, Jin‐Fang ; Roe, Anna Wang ; Yao, De‐Zhong ; Tan, Zhong‐Lin ; Northoff, Georg

Weitere Informationen

• DOI: 10.1002/advs.202403063
• URN: urn:nbn:de:101:1-2408301407591.802288139249
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:36 MESZ