A Bivalent Activatable Fluorescent Probe for Screening and Intravital Imaging of Chemotherapy‐Induced Cancer Cell Death
Abstract: The detection and quantification of apoptotic cells is a key process in cancer research, particularly during the screening of anticancer therapeutics and in mechanistic studies using preclinical models. Intravital optical imaging enables high‐resolution visualisation of cellular events in live organisms; however, there are few fluorescent probes that can reliably provide functional readouts in situ without interference from tissue autofluorescence. We report the design and optimisation of the fluorogenic probe Apotracker Red for real‐time detection of cancer cell death. The strong fluorogenic behaviour, high selectivity, and excellent stability of Apotracker Red make it a reliable optical reporter for the characterisation of the effects of anticancer drugs in cells in vitro and for direct imaging of chemotherapy‐induced apoptosis in vivo in mouse models of breast cancer.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
A Bivalent Activatable Fluorescent Probe for Screening and Intravital Imaging of Chemotherapy‐Induced Cancer Cell Death ; day:16 ; month:12 ; year:2021 ; extent:10
Angewandte Chemie / International edition. International edition ; (16.12.2021) (gesamt 10)
- Urheber
-
Barth, Nicole D.
Mendive‐Tapia, Lorena
Subiros‐Funosas, Ramon
Ghashghaei, Ouldouz
Lavilla, Rodolfo
Maiorino, Laura
He, Xue‐Yan
Dransfield, Ian
Egeblad, Mikala
Vendrell, Marc
- DOI
-
10.1002/anie.202113020
- URN
-
urn:nbn:de:101:1-2021121714034582693434
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:39 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Barth, Nicole D.
- Mendive‐Tapia, Lorena
- Subiros‐Funosas, Ramon
- Ghashghaei, Ouldouz
- Lavilla, Rodolfo
- Maiorino, Laura
- He, Xue‐Yan
- Dransfield, Ian
- Egeblad, Mikala
- Vendrell, Marc
Ähnliche Objekte (12)
A Bivalent Activatable Fluorescent Probe for Screening and Intravital Imaging of Chemotherapy‐Induced Cancer Cell Death
Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis
Intravital imaging of fluorescent markers and FRET probes by DNA tattooing
A Tetrazine‐Caged Carbon‐Dipyrromethene as a Bioorthogonally Activatable Fluorescent Probe
Intravital microcirculation imaging
Long-term monitoring of intravital biological processes using fluorescent protein-assisted NIR-II imaging
Recent Advances in the Enzyme‐Activatable Organic Fluorescent Probes for Tumor Imaging and Therapy
A Fluorescent Activatable AND‐Gate Chemokine CCL2 Enables In Vivo Detection of Metastasis‐Associated Macrophages
A Fluorescent Activatable AND‐Gate Chemokine CCL2 Enables In Vivo Detection of Metastasis‐Associated Macrophages
An activatable NIR turn-on fluorescent probe for copper (II) ion and live cell imaging
A novel method for rapid detection of a Helicobacter pylori infection using a γ-glutamyltranspeptidase-activatable fluorescent probe
Possibilities and limitations of intravital imaging
A Bivalent Activatable Fluorescent Probe for Screening and Intravital Imaging of Chemotherapy‐Induced Cancer Cell Death
Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis
Intravital imaging of fluorescent markers and FRET probes by DNA tattooing
A Tetrazine‐Caged Carbon‐Dipyrromethene as a Bioorthogonally Activatable Fluorescent Probe
Intravital microcirculation imaging
Long-term monitoring of intravital biological processes using fluorescent protein-assisted NIR-II imaging
Recent Advances in the Enzyme‐Activatable Organic Fluorescent Probes for Tumor Imaging and Therapy
A Fluorescent Activatable AND‐Gate Chemokine CCL2 Enables In Vivo Detection of Metastasis‐Associated Macrophages
A Fluorescent Activatable AND‐Gate Chemokine CCL2 Enables In Vivo Detection of Metastasis‐Associated Macrophages
An activatable NIR turn-on fluorescent probe for copper (II) ion and live cell imaging
A novel method for rapid detection of a Helicobacter pylori infection using a γ-glutamyltranspeptidase-activatable fluorescent probe
Possibilities and limitations of intravital imaging
A Bivalent Activatable Fluorescent Probe for Screening and Intravital Imaging of Chemotherapy‐Induced Cancer Cell Death
Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis
Intravital imaging of fluorescent markers and FRET probes by DNA tattooing
A Tetrazine‐Caged Carbon‐Dipyrromethene as a Bioorthogonally Activatable Fluorescent Probe
Intravital microcirculation imaging
Long-term monitoring of intravital biological processes using fluorescent protein-assisted NIR-II imaging
Recent Advances in the Enzyme‐Activatable Organic Fluorescent Probes for Tumor Imaging and Therapy
A Fluorescent Activatable AND‐Gate Chemokine CCL2 Enables In Vivo Detection of Metastasis‐Associated Macrophages
A Fluorescent Activatable AND‐Gate Chemokine CCL2 Enables In Vivo Detection of Metastasis‐Associated Macrophages
An activatable NIR turn-on fluorescent probe for copper (II) ion and live cell imaging
A novel method for rapid detection of a Helicobacter pylori infection using a γ-glutamyltranspeptidase-activatable fluorescent probe