Inhaled Pro‐Efferocytic Nanozymes Promote Resolution of Acute Lung Injury
Abstract: Acute lung injury (ALI) is a significant contributor to the morbidity and mortality of sepsis. Characterized by uncontrolled inflammation and excessive inflammatory cells infiltration in lung, ALI has been exacerbated by impaired efferocytosis (clearance of apoptotic cells by macrophages). Through specific receptor recognition and activation of downstream signaling, efferocytic macrophages promote resolution of inflammation by efficiently engulfing dying cells, avoiding the consequent release of cellular inflammatory contents. Here, inspired by the intrinsic recovery mechanism of efferocytosis, an apoptotic cell membrane (ACM) coated antioxidant nanozyme (AOzyme) is engineered, thus obtaining an inhalable pro‐efferocytic nanozyme (AOzyme@ACM). Notably, AOzyme@ACM can efficiently increase apoptotic cell removal by combing enhanced macrophages recognition of “eat me” signals through apoptotic body mimicking and scavenge of intracellular excessive reactive oxygen species (ROS), a significant barrier for efferocytosis. AOzyme@ACM can significantly inhibit inflammatory response, promote pro‐resolving (M2) phenotype transition of macrophage, and alleviate ALI in endotoxemia mice compared with AOzyme group. By addressing the critical factor in the pathogenesis of sepsis‐related ALI through restoring efferocytosis activity, the ACM‐based antioxidant nanozyme in this study is envisioned to provide a promising strategy to treat this complex and challenging disease.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Inhaled Pro‐Efferocytic Nanozymes Promote Resolution of Acute Lung Injury ; day:20 ; month:07 ; year:2022 ; extent:13
Advanced science ; (20.07.2022) (gesamt 13)
- Creator
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Ji, Haiying
Zhang, Chengmi
Xu, Fengying
Mao, Qianyun
Xia, Ran
Chen, Muqiao
Wang, Wei
Lv, Shunan
Li, Weiwei
Shi, Xueyin
- DOI
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10.1002/advs.202201696
- URN
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urn:nbn:de:101:1-2022072115180878088205
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:32 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Ji, Haiying
- Zhang, Chengmi
- Xu, Fengying
- Mao, Qianyun
- Xia, Ran
- Chen, Muqiao
- Wang, Wei
- Lv, Shunan
- Li, Weiwei
- Shi, Xueyin
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