MRI-based phenotyping for osteosarcopenic adiposity in subjects from a population-based cohort

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Abstract: Objective: Imaging biomarkers of bone, muscle, and fat by magnetic resonance imaging (MRI) may depict osteopenia, sarcopenia, and adiposity as the three different conditions of osteosarcopenic adiposity (OSA). Methods: Subjects from a prospective, population-based case–control study underwent a health assessment and 3 Tesla whole-body MRI scan. Imaging biomarkers of bone (bone marrow fat-fraction (BMFF)), skeletal muscle (skeletal muscle FF (SMFF)), and fat (total adipose tissue (TAT)) were determined. Participants were allocated to one phenotype according to the OSA complex. Results: Among 363 participants forming the study cohort, 81 (22.3%, 48.1% males, 62.4 ± 6.9 years) were allocated into the OSA subgroup. Participants with an OSA phenotype were significantly older compared to all remaining subjects and showed the highest grades of SMFF (all p < 0.005). Together with subjects from the osteopenic sarcopenia group, OSA subjects exhibited the highest amounts of BMFF and together with the three other adiposity-containing subgroups also exhibited the highest BMIs. The highest prevalence of an impaired glucose tolerance as well as significantly higher blood pressure, blood dyslipidemia, and hepatic steatosis was found in the OSA subgroup (all p < 0.005). Conclusions: MR biomarkers of bone, skeletal muscle and fat are feasible for body composition phenotyping and may allow for targeted risk stratification in suspected OSA syndrome

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Notes: Geriatrics. - 9, 6 (2024) , 150, ISSN: 2308-3417

Event: Veröffentlichung

(where): Freiburg

(who): Universität

(when): 2024

Creator: Maurer, Elke
Rospleszcz, Susanne
Rathmann, Wolfgang
Thorand, Barbara
Peters, Annette
Schlett, Christopher L.
Bamberg, Fabian
Kiefer, Lena Sophie

DOI: 10.3390/geriatrics9060150

URN: urn:nbn:de:bsz:25-freidok-2603955

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:36 AM CEST

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MRI-based phenotyping for osteosarcopenic adiposity in subjects from a population-based cohort

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