Second Generation Total Synthesis of (–)‐Preussochromone D
An improved enantioselective synthesis of the natural product (–)‐preussochromone D (3) and first insights into a possible route to the trans‐preussochromones E and F are described. Starting from commercially available 5‐hydroxy‐4H‐chromen‐4‐one, two stereocenters are established via auxiliary controlled Michael addition in excellent yield and stereoselectivity. Subsequent build‐up of the five‐membered ring gave access to (–)‐preussochromone D in an improved overall yield and less synthetic steps than previously reported. The total syntheses of preussochromones E and F on a related route were also investigated and first findings are reported herein.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Second Generation Total Synthesis of (–)‐Preussochromone D ; volume:2020 ; number:24 ; year:2020 ; pages:3699-3711 ; extent:13
European journal of organic chemistry ; 2020, Heft 24 (2020), 3699-3711 (gesamt 13)
- Creator
- DOI
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10.1002/ejoc.202000465
- URN
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urn:nbn:de:101:1-2022062409565040340220
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:38 AM CEST
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Kerste, Eric
- Beller, Marc Paul
- Koert, Ulrich
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