Sequential‐Flow Synthesis of Donepezil: A Green and Sustainable Strategy Featuring Heterogeneous Catalysis and Hydrogenation

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Abstract: An atom‐economical sequential‐flow synthesis of donepezil, a widely prescribed drug for Alzheimer's disease, was accomplished using inexpensive, commercially available precursors. This achievement was made possible by reconfiguring the synthetic route to include only heterogeneous catalytic addition and condensation reactions, with a particular emphasis on skeletal transformation and bond formation through hydrogenation processes. Notably, water was the sole byproduct in this synthesis. A crucial aspect of this work was the development of appropriate continuous‐flow processes to achieve a one‐flow synthesis. This was accomplished by implementing in‐line treatments of the main reaction stream to eliminate inhibitory factors that could affect catalyst performance in the hydrogenation steps.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Sequential‐Flow Synthesis of Donepezil: A Green and Sustainable Strategy Featuring Heterogeneous Catalysis and Hydrogenation ; day:17 ; month:09 ; year:2024 ; extent:9
Chemistry - a European journal ; (17.09.2024) (gesamt 9)

Creator: Ishitani, Haruro
Sogo, Hideyuki
Furiya, Yuichi
Kobayashi, Shu

DOI: 10.1002/chem.202402128

URN: urn:nbn:de:101:1-2409171417011.112580428509

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:37 AM CEST

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Ishitani, Haruro
Sogo, Hideyuki
Furiya, Yuichi
Kobayashi, Shu

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Sequential‐Flow Synthesis of Donepezil: A Green and Sustainable Strategy Featuring Heterogeneous Catalysis and Hydrogenation

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