Monocyte progenitors give rise to multinucleated giant cells
Abstract: The immune response to mycobacteria is characterized by granuloma formation, which features multinucleated giant cells as a unique macrophage type. We previously found that multinucleated giant cells result from Toll-like receptor-induced DNA damage and cell autonomous cell cycle modifications. However, the giant cell progenitor identity remained unclear. Here, we show that the giant cell-forming potential is a particular trait of monocyte progenitors. Common monocyte progenitors potently produce cytokines in response to mycobacteria and their immune-active molecules. In addition, common monocyte progenitors accumulate cholesterol and lipids, which are prerequisites for giant cell transformation. Inducible monocyte progenitors are so far undescribed circulating common monocyte progenitor descendants with high giant cell-forming potential. Monocyte progenitors are induced in mycobacterial infections and localize to granulomas. Accordingly, they exhibit important immunological functions in mycobacterial infections. Moreover, their signature trait of high cholesterol metabolism may be piggy-backed by mycobacteria to create a permissive niche
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Nature communications. - 12 (2021) , 2027, ISSN: 2041-1723
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2021
- Creator
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Lößlein, Anne
Lohrmann, Florens
Scheuermann, Lisa
Gharun, Kourosh
Neuber, Jana
Kolter, Julia
Forde, Aaron James
Kleimeyer, Christian
Poh, Ying Yee
Mack, Matthias
Triantafyllopoulou, Antigoni
Dunlap, Micah D.
Khader, Shabaana A.
Seidl, Maximilian
Hölscher, Alexandra
Hölscher, Christoph
Guan, Xue Li
Dorhoi, Anca
Henneke, Philipp
- DOI
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10.1038/s41467-021-22103-5
- URN
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urn:nbn:de:bsz:25-freidok-1947265
- Rights
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Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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25.03.2025, 1:54 PM CET
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Lößlein, Anne
- Lohrmann, Florens
- Scheuermann, Lisa
- Gharun, Kourosh
- Neuber, Jana
- Kolter, Julia
- Forde, Aaron James
- Kleimeyer, Christian
- Poh, Ying Yee
- Mack, Matthias
- Triantafyllopoulou, Antigoni
- Dunlap, Micah D.
- Khader, Shabaana A.
- Seidl, Maximilian
- Hölscher, Alexandra
- Hölscher, Christoph
- Guan, Xue Li
- Dorhoi, Anca
- Henneke, Philipp
- Universität
Time of origin
- 2021