Ruthenium (II)‐Catalyzed Hydrogen Isotope Exchange of Pharmaceutical Drugs by C−H Deuteration and C−H Tritiation
Abstract: Well‐defined ruthenium (II) biscarboxylate complexes enabled selective ortho‐deuteration with weakly‐coordinating, synthetically useful carboxylic acid with outstanding levels of isotopic labeling. The robust nature of the catalytic system was reflected by a broad functional group tolerance in an operationally‐simple manner, allowing the isotope labeling of challenging pharmaceuticals and bioactive heterocyclic motifs. The synthetic power of our method was highlighted by the selective tritium‐labeling of repaglinide, an antidiabetic drug, providing access to defined tritium labeled therapeutics.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Ruthenium (II)‐Catalyzed Hydrogen Isotope Exchange of Pharmaceutical Drugs by C−H Deuteration and C−H Tritiation ; volume:12 ; number:1 ; year:2020 ; pages:100-104 ; extent:5
ChemCatChem ; 12, Heft 1 (2020), 100-104 (gesamt 5)
- Creator
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Müller, Valentin
Weck, Remo
Derdau, Volker
Ackermann, Lutz
- DOI
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10.1002/cctc.201902051
- URN
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urn:nbn:de:101:1-2022062410290560811405
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:29 AM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Müller, Valentin
- Weck, Remo
- Derdau, Volker
- Ackermann, Lutz
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