Association between 15 insertion/deletion genetic polymorphisms and risk of schizophrenia using pooled samples
Abstract: Schizophrenia is a psychiatric syndrome that affects approximately 1 % of the world population and is among the top 10 reasons for disability. In this case-control study, we investigated the association between 15 insertion/deletion (Indel) polymorphisms and schizophrenia risk using pooled samples. In the present case-control study, 361 individuals with schizophrenia and 360 healthy individuals were included in the study. We examined the insertion/deletion polymorphisms in APOB, ADRA2B, PDCD6IP, LRPAP1, TLR2, DHFR, VEGF, HLA-G, TPA, DBH, UCP2, FADS2, MDM2, TP53 and SLC6A4 genes. Our results revealed that the Del allele of the HLA-G 14bp Indel polymorphism increased the risk of schizophrenia (OR=1.23, 95 % CI=1.01-1.52, p=0.045) and the Alu- allele of the TPA Alu+/Alu- polymorphism negatively associated with the schizophrenia risk (OR=0.67, 95 % CI=0.54-0.82, p<0.001). https://www.excli.de/index.php/excli/article/view/5734
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Association between 15 insertion/deletion genetic polymorphisms and risk of schizophrenia using pooled samples ; volume:22 ; year:2023
EXCLI journal ; 22 (2023)
- Urheber
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Bordbar, Maedeh
Saadat, Mostafa
- DOI
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10.17179/excli2022-5734
- URN
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urn:nbn:de:101:1-2023033103133347677006
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:45 MESZ
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Beteiligte
- Bordbar, Maedeh
- Saadat, Mostafa
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