Long-term stable modifications of silicone elastomer for improved hemocompatibility
Abstract: Silicone elastomers are well established in medical engineering and particularly in blood-contacting applications such as catheters and medical tubing. Still, their intrinsic surface properties have potential for improvement. For example, hydrophobicity reduction can be a way to provide better hemocompatibility. In this study, several bulk and surface modifications of silicone elastomers using polyethylene glycol (PEG) were investigated. All modifications induced long-term (2 months), stable wettability of the surface. Moreover, cytotoxicity testing demonstrated their suitability as implant material. Hemocompatibility was investigated through a thrombin generation assay as well as a platelet adhesion study combining an enzymatic assay and a scanning electron microscope analysis. That the hemocompatibility of silicone was considerably improved thanks to the PEG modifications could be shown. The study introduces easily processable, cost-efficient, and long-term stable hydrophilic modifications of silicone elastomer for improved hemocompatibility.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Long-term stable modifications of silicone elastomer for improved hemocompatibility ; volume:2 ; number:1 ; year:2016 ; pages:21-25 ; extent:5
Current directions in biomedical engineering ; 2, Heft 1 (2016), 21-25 (gesamt 5)
- Creator
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Boudot, Cécile
Burkhardt, Sarah
Haerst, Miriam
- DOI
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10.1515/cdbme-2016-0008
- URN
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urn:nbn:de:101:1-2410141627233.131883927454
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:29 AM CEST
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Associated
- Boudot, Cécile
- Burkhardt, Sarah
- Haerst, Miriam
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