Closed-loop control system for well-defined oxygen supply in micro-physiological systems

Abstract: To improve cell vitality, sufficient oxygen supply is an important factor. A deficiency in oxygen is called Hypoxia and can influence for example tumor growth or inflammatory processes. Hypoxia assays are usually performed with the help of animal or static human cell culture models. The main disadvantage of these methods is that the results are hardly transferable to the human physiology. Microfluidic 3D cell cultivation systems for perfused hypoxia assays may overcome this issue since they can mimic the in-vivo situation in the human body much better. Such a Hypoxia-on-a-Chip system was recently developed. The chip system consists of several individually laser-structured layers which are bonded using a hot press or chemical treatment. Oxygen sensing spots are integrated into the system which can be monitored continuously with an optical sensor by means of fluorescence lifetime detection. Hereby presented is the developed hard- and software requiered to control the oxygen content within this microfluidic system. This system forms a closed-loop control system which is parameterized and evaluated.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Closed-loop control system for well-defined oxygen supply in micro-physiological systems ; volume:3 ; number:2 ; year:2017 ; pages:363-366 ; extent:4 ; Current directions in biomedical engineering ; 3, Heft 2 (2017), 363-366 (gesamt 4)

Contributors, Places and Time

• Creator: Steege, Tobias ; Busek, Mathias ; Grünzner, Stefan ; Lasagni, Andrés Fabían ; Sonntag, Frank

Further information

• DOI: 10.1515/cdbme-2017-0075
• URN: urn:nbn:de:101:1-2023030713135399638922
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:45 AM CEST