Developing a Blood Cell‐Based Diagnostic Test for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Peripheral Blood Mononuclear Cells
Abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by debilitating fatigue that profoundly impacts patients' lives. Diagnosis of ME/CFS remains challenging, with most patients relying on self‐report, questionnaires, and subjective measures to receive a diagnosis, and many never receiving a clear diagnosis at all. In this study, a single‐cell Raman platform and artificial intelligence are utilized to analyze blood cells from 98 human subjects, including 61 ME/CFS patients of varying disease severity and 37 healthy and disease controls. These results demonstrate that Raman profiles of blood cells can distinguish between healthy individuals, disease controls, and ME/CFS patients with high accuracy (91%), and can further differentiate between mild, moderate, and severe ME/CFS patients (84%). Additionally, specific Raman peaks that correlate with ME/CFS phenotypes and have the potential to provide insights into biological changes and support the development of new therapeutics are identified. This study presents a promising approach for aiding in the diagnosis and management of ME/CFS and can be extended to other unexplained chronic diseases such as long COVID and post‐treatment Lyme disease syndrome, which share many of the same symptoms as ME/CFS.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Developing a Blood Cell‐Based Diagnostic Test for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Peripheral Blood Mononuclear Cells ; day:31 ; month:08 ; year:2023 ; extent:11
Advanced science ; (31.08.2023) (gesamt 11)
- Creator
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Xu, Jiabao
Lodge, Tiffany
Kingdon, Caroline
Strong, James W. L.
Maclennan, John
Lacerda, Eliana
Kujawski, Slawomir
Zalewski, Pawel
Huang, Wei E.
Morten, Karl J.
- DOI
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10.1002/advs.202302146
- URN
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urn:nbn:de:101:1-2023090115132458538424
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 11:03 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Xu, Jiabao
- Lodge, Tiffany
- Kingdon, Caroline
- Strong, James W. L.
- Maclennan, John
- Lacerda, Eliana
- Kujawski, Slawomir
- Zalewski, Pawel
- Huang, Wei E.
- Morten, Karl J.
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Commentary on human pluripotent stem cell-based blood–brain barrier models
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Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome
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