Hydrogen Bond Directed ortho ‐Selective C−H Borylation of Secondary Aromatic Amides
Abstract: Reported is an iridium catalyst for ortho‐selective C−H borylation of challenging secondary aromatic amide substrates, and the regioselectivity is controlled by hydrogen‐bond interactions. The BAIPy‐Ir catalyst forms three hydrogen bonds with the substrate during the crucial activation step, and allows ortho‐C−H borylation with high selectivity. The catalyst displays unprecedented ortho selectivities for a wide variety of substrates that differ in electronic and steric properties, and the catalyst tolerates various functional groups. The regioselective C−H borylation catalyst is readily accessible and converts substrates on gram scale with high selectivity and conversion.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Hydrogen Bond Directed ortho ‐Selective C−H Borylation of Secondary Aromatic Amides ; volume:58 ; number:37 ; year:2019 ; pages:13039-13043 ; extent:5
Angewandte Chemie / International edition. International edition ; 58, Heft 37 (2019), 13039-13043 (gesamt 5)
- Urheber
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Bai, Shao‐Tao
Bheeter, Charles B.
Reek, Joost N. H.
- DOI
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10.1002/anie.201907366
- URN
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urn:nbn:de:101:1-2022071209223338403591
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:23 MESZ
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Beteiligte
- Bai, Shao‐Tao
- Bheeter, Charles B.
- Reek, Joost N. H.
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