Strong Antibiotic Activity of the Myxocoumarin Scaffold in vitro and in vivo

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Abstract: The increasing emergence of resistances against established antibiotics is a substantial threat to human health. The discovery of new compounds with potent antibiotic activity is thus of utmost importance. Within this work, we identify strong antibiotic activity of the natural product myxocoumarin B from Stigmatella aurantiaca MYX‐030 against a range of clinically relevant bacterial pathogens, including clinical isolates of MRSA. A focused library of structural analogs was synthesized to explore initial structure‐activity relationships and to identify equipotent myxocoumarin derivatives devoid of the natural nitro substituent to significantly streamline synthetic access. The cytotoxicity of the myxocoumarins as well as their potential to cure bacterial infections in vivo was established using a zebrafish model system. Our results reveal the exceptional antibiotic activity of the myxocoumarin scaffold and hence its potential for the development of novel antibiotics.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Strong Antibiotic Activity of the Myxocoumarin Scaffold in vitro and in vivo ; day:26 ; month:04 ; year:2022 ; extent:1
Chemistry - a European journal ; (26.04.2022) (gesamt 1)

Creator: Hertrampf, Gesa
Kusserow, Kalina
Vojnovic, Sandra
Pavic, Aleksandar
Müller, Jonas I.
Nikodinovic‐Runic, Jasmina
Gulder, Tobias A. M.

DOI: 10.1002/chem.202200394

URN: urn:nbn:de:101:1-2022042715030554644471

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:23 AM CEST

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Hertrampf, Gesa
Kusserow, Kalina
Vojnovic, Sandra
Pavic, Aleksandar
Müller, Jonas I.
Nikodinovic‐Runic, Jasmina
Gulder, Tobias A. M.

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