Recent Applications of Carbon‐Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds

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Abstract: Carbon‐nitrogen (C−N) lyases are enzymes that normally catalyze the cleavage of C−N bonds. Reversing this reaction towards carbon‐nitrogen bond formation can be a powerful approach to prepare valuable compounds that could find applications in everyday life. This review focuses on recent (last five years) applications of native and engineered C−N lyases, either as stand‐alone biocatalysts or as part of multienzymatic and chemoenzymatic cascades, in enantioselective synthesis of noncanonical amino acids and dinitrogen‐fused heterocycles, which are useful tools for neurobiological research and important synthetic precursors to pharmaceuticals and food additives.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Recent Applications of Carbon‐Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds ; volume:21 ; number:19 ; year:2020 ; pages:2733-2742 ; extent:10
ChemBioChem ; 21, Heft 19 (2020), 2733-2742 (gesamt 10)

Creator: Zhang, Jielin
Abidin, Mohammad Z.
Saravanan, Thangavelu
Poelarends, Gerrit

DOI: 10.1002/cbic.202000214

URN: urn:nbn:de:101:1-2022062005120271879908

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:37 AM CEST

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Zhang, Jielin
Abidin, Mohammad Z.
Saravanan, Thangavelu
Poelarends, Gerrit

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Recent Applications of Carbon‐Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds

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