Research in practice: towards deciphering the role of epidermal proteases in recessive dystrophic epidermolysis bullosa progression
Abstract: Recessive dystrophic epidermolysis bullosa (RDEB) is an incurable severe skin disease caused by loss of collagen VII, an extracellular protein that ensures skin cohesion. It manifests in skin blistering and unresolved cycles of wounding and healing that progressively lead to dermal stiffening and early development of aggressive cutaneous squamous cell carcinomas. Inflammation and subsequent tissue fibrosis highly contribute to RDEB pathogenicity and targeting them could provide new therapeutic options. Kallikreins (KLKs) are epidermal secreted proteases, which contribute to skin desquamation and inflammation. Kallikreins are involved in the pathogenesis of several inflammatory skin disorders, but interestingly also in the initiation and progression of different cancers. Our project aims at deciphering the role of KLKs in inflammation, fibrosis, and tumor development in RDEB
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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JDDG: Journal der Deutschen Dermatologischen Gesellschaft. - 19, 6 (2021) , 828-832, ISSN: 1610-0387
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2021
- Creator
- DOI
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10.1111/ddg.14396
- URN
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urn:nbn:de:bsz:25-freidok-1947537
- Rights
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Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 11:00 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Nauroy, Pauline
- Zingkou, Eleni
- Sotiropoulou, Georgia
- Kiritsi, Dimitra
- Universität
Time of origin
- 2021
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Clinical trial of ABCB5-positive mesenchymal stem cells for recessive dystrophic epidermolysis bullosa
STAT3 targeting in dystrophic epidermolysis bullosa
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Treatment of Epidermolysis bullosa acquisita with dupilumab
Recent advances in understanding and managing epidermolysis bullosa
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Betulin-based oleogel to improve wound healing in dystrophic epidermolysis bullosa: a prospective controlled proof-of-concept study
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