Consolidation of the Oxidant‐Free Au (I)/Au (III) Catalysis Enabled by the Hemilabile Ligand Strategy
Abstract: In this minireview we survey the challenges and strategies in gold redox catalysis. Gold's reluctance to oxidative addition reactions due to its high redox potential limits its applicability. Initial attempts to overcome this problem focused on the use of sacrificial external oxidants in stoichiometric amounts to bring Au (I) compounds to Au (III) reactive species. Recently, innovative approaches focused on employing hemilabile ligands, which are capable of coordinating to Au (I) and stabilizing square‐planar Au (III) intermediates, thus facilitating oxidative addition steps and enabling oxidant‐free catalysis. Notable examples include the use of the (P^N) bidendate MeDalphos ligand to achieve various cross‐coupling reactions via oxidative addition Au (I)/Au (III). Importantly, hemilabile ligand‐enabled catalysis allows merging oxidative addition with π‐activation, such as oxy‐ and aminoarylation of alkenols and alkenamines using organohalides, expanding gold‘s versatility in C−C and C‐heteroatom bond formations and unprecedented cyclizations. Moreover, recent advancements in enantioselective catalysis using chiral hemilabile (P^N) ligands are also surveyed. Strikingly, versatile bidentate (C^N) hemilabile ligands as competitors of MeDalphos have appeared recently, by designing scaffolds where phosphine groups are substituted by N‐heterocyclic or mesoionic carbenes. Overall, these approaches highlight the evolving landscape of gold redox catalysis and its tremendous potential in a broad scope of transformations.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Consolidation of the Oxidant‐Free Au (I)/Au (III) Catalysis Enabled by the Hemilabile Ligand Strategy ; day:14 ; month:05 ; year:2024 ; extent:19
Angewandte Chemie / International edition. International edition ; (14.05.2024) (gesamt 19)
- Creator
- DOI
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10.1002/anie.202405824
- URN
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urn:nbn:de:101:1-2405151425287.044430392203
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 11:01 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Font, Pau
- Valdés, Hugo
- Ribas, Xavi
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Consolidation of the Oxidant‐Free Au (I)/Au (III) Catalysis Enabled by the Hemilabile Ligand Strategy
Fundamental Basis for Implementing Oxidant‐Free Au(I)/Au(III) Catalysis
Mechanistic Insights about the Ligand‐Enabled Oxy‐arylation/vinylation of Alkenes via Au (I)/Au (III) Catalysis
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Les travaux de consolidation souterraine au Grand-Palais
Au-Fe system: application in electro-catalysis
Anion–π Catalysis Enabled by the Mechanical Bond **
Anion–π Catalysis Enabled by the Mechanical Bond **
Cross-Electrophile Coupling Enabled by Visible-Light Palladium Catalysis
Enantioselective Synthesis of Tertiary Nitroalkanes Enabled by Enzyme Catalysis
Asymmetric dihydroboration of allenes enabled by ligand relay catalysis
Nanoconfinement steers nonradical pathway transition in single atom fenton-like catalysis for improving oxidant utilization
Consolidation of the Oxidant‐Free Au (I)/Au (III) Catalysis Enabled by the Hemilabile Ligand Strategy
Fundamental Basis for Implementing Oxidant‐Free Au(I)/Au(III) Catalysis
Mechanistic Insights about the Ligand‐Enabled Oxy‐arylation/vinylation of Alkenes via Au (I)/Au (III) Catalysis
Silver‐Free Au(I) Catalysis Enabled by Bifunctional Urea‐ and Squaramide‐Phosphine Ligands via H‐Bonding
Les travaux de consolidation souterraine au Grand-Palais
Au-Fe system: application in electro-catalysis
Anion–π Catalysis Enabled by the Mechanical Bond **
Anion–π Catalysis Enabled by the Mechanical Bond **
Cross-Electrophile Coupling Enabled by Visible-Light Palladium Catalysis
Enantioselective Synthesis of Tertiary Nitroalkanes Enabled by Enzyme Catalysis
Asymmetric dihydroboration of allenes enabled by ligand relay catalysis