Development of Small Molecule Inhibitors Targeting HSP90 C-terminal Dimerization in BCR-ABL1 positive Leukemia

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Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Notes: Düsseldorf, Heinrich-Heine-Universität, Dissertation, 2023

Keyword: Hitzeschock-Proteine

Event: Veröffentlichung

(where): Düsseldorf

(who): Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf

(when): 2025

Creator: Dienstbier, Niklas

Contributor: Kurz, Thomas
Hauer, Julia

URN: urn:nbn:de:hbz:061-20250206-095055-9

Rights: Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:32 AM CEST

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Associated

Dienstbier, Niklas
Kurz, Thomas
Hauer, Julia
Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf

Time of origin

2025

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Decrypting the role of HSP90α and β isoforms in BCR-ABL1+ leukemia and Characterization of Small Molecule HSP90 Inhibitors and Degraders

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BCR/ABL1 and BCR are under the transcriptional control of the MYC oncogene

FISH mapping of Philadelphia negative BCR/ABL1 positive CML

Approach to Diagnosis of BCR::ABL1-Negative Myeloproliferative Neoplasms

Decrypting the role of HSP90α and β isoforms in BCR-ABL1+ leukemia and Characterization of Small Molecule HSP90 Inhibitors and Degraders

Repurposing pexmetinib as an inhibitor of TKI-resistant BCR::ABL1

Targeting Poly(ADP)ribose polymerase in BCR/ABL1-positive cells

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The role of proteostasis in BCR-ABL1-positive acute lymphoblastic leukemia

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Pre-B cell receptor signaling prevents malignant transformation by BCR-ABL1

Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells

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BCR/ABL1 and BCR are under the transcriptional control of the MYC oncogene

FISH mapping of Philadelphia negative BCR/ABL1 positive CML

Approach to Diagnosis of BCR::ABL1-Negative Myeloproliferative Neoplasms

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Repurposing pexmetinib as an inhibitor of TKI-resistant BCR::ABL1

Targeting Poly(ADP)ribose polymerase in BCR/ABL1-positive cells

Impact of BCR::ABL1 single nucleotide variants on asciminib efficacy

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The role of proteostasis in BCR-ABL1-positive acute lymphoblastic leukemia

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Development of Small Molecule Inhibitors Targeting HSP90 C-terminal Dimerization in BCR-ABL1 positive Leukemia

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Other Objects (12)

Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells

Genomische BCR-ABL1-Bruchpunkte bei kindlichen Leukämien

BCR/ABL1 and BCR are under the transcriptional control of the MYC oncogene

FISH mapping of Philadelphia negative BCR/ABL1 positive CML

Approach to Diagnosis of BCR::ABL1-Negative Myeloproliferative Neoplasms

Decrypting the role of HSP90α and β isoforms in BCR-ABL1+ leukemia and Characterization of Small Molecule HSP90 Inhibitors and Degraders

Repurposing pexmetinib as an inhibitor of TKI-resistant BCR::ABL1

Targeting Poly(ADP)ribose polymerase in BCR/ABL1-positive cells

Impact of BCR::ABL1 single nucleotide variants on asciminib efficacy

Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1T315I and BCR-ABL1T315I-E255K

The role of proteostasis in BCR-ABL1-positive acute lymphoblastic leukemia

Pre-B cell receptor signaling prevents malignant transformation by BCR-ABL1

Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells

Genomische BCR-ABL1-Bruchpunkte bei kindlichen Leukämien

BCR/ABL1 and BCR are under the transcriptional control of the MYC oncogene

FISH mapping of Philadelphia negative BCR/ABL1 positive CML

Approach to Diagnosis of BCR::ABL1-Negative Myeloproliferative Neoplasms

Decrypting the role of HSP90α and β isoforms in BCR-ABL1+ leukemia and Characterization of Small Molecule HSP90 Inhibitors and Degraders

Repurposing pexmetinib as an inhibitor of TKI-resistant BCR::ABL1

Targeting Poly(ADP)ribose polymerase in BCR/ABL1-positive cells

Impact of BCR::ABL1 single nucleotide variants on asciminib efficacy

Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1T315I and BCR-ABL1T315I-E255K

The role of proteostasis in BCR-ABL1-positive acute lymphoblastic leukemia

Pre-B cell receptor signaling prevents malignant transformation by BCR-ABL1

Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells

Genomische BCR-ABL1-Bruchpunkte bei kindlichen Leukämien

BCR/ABL1 and BCR are under the transcriptional control of the MYC oncogene

FISH mapping of Philadelphia negative BCR/ABL1 positive CML

Approach to Diagnosis of BCR::ABL1-Negative Myeloproliferative Neoplasms

Decrypting the role of HSP90α and β isoforms in BCR-ABL1+ leukemia and Characterization of Small Molecule HSP90 Inhibitors and Degraders

Repurposing pexmetinib as an inhibitor of TKI-resistant BCR::ABL1

Targeting Poly(ADP)ribose polymerase in BCR/ABL1-positive cells

Impact of BCR::ABL1 single nucleotide variants on asciminib efficacy

Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1T315I and BCR-ABL1T315I-E255K

The role of proteostasis in BCR-ABL1-positive acute lymphoblastic leukemia

Pre-B cell receptor signaling prevents malignant transformation by BCR-ABL1

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