Hemisphere-specific spatial representation by hippocampal granule cells
Abstract: The dentate gyrus (DG) output plays a key role in the emergence of spatial and contextual map representation within the hippocampus during learning. Differences in neuronal network activity have been observed between left and right CA1-3 areas, implying lateralization in spatial coding properties. Whether bilateral differences of DG granule cell (GC) assemblies encoding spatial and contextual information exist remains largely unexplored. Here, we employed two-photon calcium imaging of the left or the right DG to record the activity of GC populations over five consecutive days in head-fixed mice navigating through familiar and novel virtual environments. Imaging revealed similar mean GC activity on both sides. However, spatial tuning, context-selectivity and run-to-run place field reliability was markedly higher for DG place cells in the left than the right hemisphere. Moreover, the proportion of GCs reconfiguring their place fields between contexts was greater in the left DG. Thus, our data suggest that contextual information is differentially processed by GC populations depending on the hemisphere, with higher context discrimination in the left but a bias towards generalization in the right DG
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Notes
-
Nature communications. - 13, 1 (2022) , 6227, ISSN: 2041-1723
- Event
-
Veröffentlichung
- (where)
-
Freiburg
- (who)
-
Universität
- (when)
-
2022
- Creator
- DOI
-
10.1038/s41467-022-34039-5
- URN
-
urn:nbn:de:bsz:25-freidok-2304606
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
25.03.2025, 1:42 PM CET
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Cholvin, Thibault
- Bartos, Marlene
- Universität
Time of origin
- 2022
Other Objects (12)
Dendritic integration in hippocampal dentate gyrus granule cells
Dendritic integration in hippocampal dentate gyrus granule cells
Functional integration and structural development of adult newborn hippocampal granule cells
Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells
Heat-shock induces granule cell dispersion and microgliosis in hippocampal slice cultures
Tetrodotoxin prevents heat-shock induced granule cell dispersion in hippocampal slice cultures
CEBPE-mutant specific granule deficiency correlates with aberrant granule organization and substantial proteome alterations in neutrophils
Role of calcium in spontaneous neurotransmitter release in synapses on hippocampal granule cells
Live microscopy of RNA granule sorting in hippocampal neurons in space and time
Borna disease virus-mediated cell death of hippocampal granule cells Is Associated with Autophagy
On the structural maturation, plasticity, function and computation of adult-born hippocampal granule cells
Structural development of postnatally generated dentate granule cells in organotypic entorhino-hippocampal slice cultures
Dendritic integration in hippocampal dentate gyrus granule cells
Dendritic integration in hippocampal dentate gyrus granule cells
Functional integration and structural development of adult newborn hippocampal granule cells
Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells
Heat-shock induces granule cell dispersion and microgliosis in hippocampal slice cultures
Tetrodotoxin prevents heat-shock induced granule cell dispersion in hippocampal slice cultures
CEBPE-mutant specific granule deficiency correlates with aberrant granule organization and substantial proteome alterations in neutrophils
Role of calcium in spontaneous neurotransmitter release in synapses on hippocampal granule cells
Live microscopy of RNA granule sorting in hippocampal neurons in space and time
Borna disease virus-mediated cell death of hippocampal granule cells Is Associated with Autophagy
On the structural maturation, plasticity, function and computation of adult-born hippocampal granule cells
Structural development of postnatally generated dentate granule cells in organotypic entorhino-hippocampal slice cultures
Dendritic integration in hippocampal dentate gyrus granule cells
Dendritic integration in hippocampal dentate gyrus granule cells
Functional integration and structural development of adult newborn hippocampal granule cells
Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells
Heat-shock induces granule cell dispersion and microgliosis in hippocampal slice cultures
Tetrodotoxin prevents heat-shock induced granule cell dispersion in hippocampal slice cultures
CEBPE-mutant specific granule deficiency correlates with aberrant granule organization and substantial proteome alterations in neutrophils
Role of calcium in spontaneous neurotransmitter release in synapses on hippocampal granule cells
Live microscopy of RNA granule sorting in hippocampal neurons in space and time
Borna disease virus-mediated cell death of hippocampal granule cells Is Associated with Autophagy
On the structural maturation, plasticity, function and computation of adult-born hippocampal granule cells