Activity Sensing of Coagulation and Fibrinolytic Proteases

Abstract: The blood coagulation cascade is a complex physiological process involving the action of multiple coupled enzymes, cofactors, and substrates, ultimately leading to clot formation. Serine proteases have a crucial role, and aberrations in their activity can lead to life‐threatening bleeding disorders and thrombosis. This review summarizes the essential proteases involved in blood coagulation and fibrinolysis, the endogenous peptide sequences they recognize and hydrolyze, and synthetic peptide probes based on these sequences to measure their activity. The information in this review can contribute to developing novel anticoagulant therapies and specific substrates for point‐of‐care diagnosis of coagulation pathologies.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Activity Sensing of Coagulation and Fibrinolytic Proteases ; day:07 ; month:02 ; year:2023 ; extent:17 ; Chemistry - a European journal ; (07.02.2023) (gesamt 17)

Contributors, Places and Time

• Creator: Sondag, Daan ; Verhoeven, Stijn ; Löwik, Dennis W. P. M. ; van Geffen, Mark ; Veer, Cornelis van't ; van Heerde, Waander L. ; Boltje, Thomas J. ; Rutjes, Floris P. J. T.

Further information

• DOI: 10.1002/chem.202203473
• URN: urn:nbn:de:101:1-2023020714245504087036
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:47 AM CEST