Nanocarriers for delivery of siRNA as gene silencing mediator

Abstract: The term nanocarrier refers to sub-micrometric particles of less than 100 nm, designed to transport, distribute, and release nanotechnology-based drug delivery systems. siRNA therapy is a novel strategy that has great utility for a variety of treatments, however naked siRNA delivery has not been an effective strategy, resulting in the necessary use of nanocarriers for delivery. This review aims to highlight the versatility of carriers based on smart drug delivery systems. The nanocarriers based on nanoparticles as siRNA DDS have provided a set of very attractive advantages related to improved physicochemical properties, such as high surface-to-volume ratio, versatility to package siRNA, provide a dual function to both protect extracellular barriers that lead to elimination and overcome intracellular barriers limiting cytosolic delivery, and possible chemical modifications on the nanoparticle surface to improve stability and targeting. Lipid and polymeric nanocarriers have proven to.... https://www.excli.de/index.php/excli/article/view/4975

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Nanocarriers for delivery of siRNA as gene silencing mediator ; volume:21 ; year:2022 ; EXCLI journal ; 21 (2022)

Contributors, Places and Time

• Creator: Morales-Becerril, Aideé ; Aranda-Lara, Liliana ; Isaac-Olivé, Keila ; Ocampo-García, Blanca E. ; Morales-Avila, Enrique

Further information

• DOI: 10.17179/excli2022-4975
• URN: urn:nbn:de:101:1-2022081813254531756160
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:22 AM CEST